GSM6881392

Dataset: gse221521 • Sample: DR group R_JS002 • Status: Diabetic retinopathy
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Quality Control Metrics

15,528,487 Total counts Group median: 12,498,211 • 94.0%ile (↑ High)
29,394 Detected genes Group median: 27,368 • 99.2%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 29.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

43.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 61.4%
FOXO3 Insulin/IGF-1 Signaling 12.85
bar=donor   line=cohort median 		12.92 47.4%
CETP Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.40 2.3%
SIRT6 Sirtuin Family 2.94
bar=donor   line=cohort median 		3.67 17.9%
SIRT1 Sirtuin Family 4.73
bar=donor   line=cohort median 		3.48 85.8%
SIRT3 Sirtuin Family 0.92
bar=donor   line=cohort median 		1.10 21.0%
IGF1R Insulin/IGF-1 Signaling 4.77
bar=donor   line=cohort median 		4.33 56.2%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 10.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 63.0%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 25.48
bar=donor   line=cohort median 		35.28 30.8%
TP53 Tumor Suppression 5.71
bar=donor   line=cohort median 		3.83 89.4%
SHC1 Signal Transduction 8.84
bar=donor   line=cohort median 		8.77 52.1%
ACE Signal Transduction 0.41
bar=donor   line=cohort median 		0.39 53.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 8,639.9 206,883
2 MT-RNR2 ENSG00000210082 Mt_rRNA 5,831.2 141,168
3 MT-CO2 ENSG00000198712 protein_coding 5,325.8 56,568
4 MT-ATP6 ENSG00000198899 protein_coding 5,210.1 55,096
5 MT-ATP8 ENSG00000228253 protein_coding 3,767.4 12,110
6 S100A9 ENSG00000163220 protein_coding 3,662.4 32,587
7 RPL13AP5 ENSG00000236552 processed_pseudogene 3,585.7 34,076
8 MT-ND4 ENSG00000198886 protein_coding 3,566.1 76,309
9 RPS28P7 ENSG00000227097 processed_pseudogene 3,407.3 11,111
10 MT-ND4L ENSG00000212907 protein_coding 3,183.2 14,681

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 714.0
bar=donor   line=cohort median 		1,223.7 1,385.4 11.7%
2 S100A9 protein_coding 3,662.4
bar=donor   line=cohort median 		7,732.1 9,235.1 10.6%
3 IL1B protein_coding 4.9
bar=donor   line=cohort median 		4.9 6.1 41.2%
4 CXCL8 protein_coding 371.0
bar=donor   line=cohort median 		197.4 207.4 77.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.8
bar=donor   line=cohort median 		2.9 2.4 38.1%
6 FCGR3B protein_coding 77.8
bar=donor   line=cohort median 		108.9 129.3 21.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 866.3
bar=donor   line=cohort median 		581.4 706.2 64.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 99.0
bar=donor   line=cohort median 		51.6 56.4 86.8%
9 CD3E protein_coding 57.3
bar=donor   line=cohort median 		38.1 37.7 85.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 8.3
bar=donor   line=cohort median 		3.0 3.1 93.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 315.4
bar=donor   line=cohort median 		252.2 281.6 59.8%
12 GNLY protein_coding 67.8
bar=donor   line=cohort median 		58.9 70.7 44.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 412.5
bar=donor   line=cohort median 		585.0 582.1 36.0%
14 HBA1 protein_coding 2,554.8
bar=donor   line=cohort median 		1,960.4 1,960.7 61.4%
15 HBA2 protein_coding 568.7
bar=donor   line=cohort median 		1,080.5 1,083.5 27.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,639.9
bar=donor   line=cohort median 		6,740.9 6,938.4 79.0%
17 MT-CO2 protein_coding 5,325.8
bar=donor   line=cohort median 		5,693.7 5,810.8 36.0%
18 MT-ND1 protein_coding 2,608.6
bar=donor   line=cohort median 		3,876.8 3,718.2 15.3%
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