GSM6881394

Dataset: gse221521 • Sample: DR group R_JS003 • Status: Diabetic retinopathy
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Quality Control Metrics

12,498,211 Total counts Group median: 12,498,211 • 45.3%ile (≈ Median)
27,929 Detected genes Group median: 27,368 • 87.8%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 33.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

58.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.30
bar=donor   line=cohort median 		0.17 81.1%
FOXO3 Insulin/IGF-1 Signaling 11.91
bar=donor   line=cohort median 		12.92 39.1%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 10.6%
SIRT6 Sirtuin Family 4.64
bar=donor   line=cohort median 		3.67 86.3%
SIRT1 Sirtuin Family 2.72
bar=donor   line=cohort median 		3.48 16.8%
SIRT3 Sirtuin Family 0.97
bar=donor   line=cohort median 		1.10 28.2%
IGF1R Insulin/IGF-1 Signaling 7.26
bar=donor   line=cohort median 		4.33 90.9%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 55.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 49.0%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 45.3%
IRS2 Insulin/IGF-1 Signaling 31.90
bar=donor   line=cohort median 		35.28 43.8%
TP53 Tumor Suppression 5.38
bar=donor   line=cohort median 		3.83 83.2%
SHC1 Signal Transduction 12.60
bar=donor   line=cohort median 		8.77 99.7%
ACE Signal Transduction 1.01
bar=donor   line=cohort median 		0.39 96.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,043.4 156,724
2 S100A9 ENSG00000163220 protein_coding 7,920.3 56,721
3 MT-CO1 ENSG00000198804 protein_coding 6,134.8 118,231
4 HBA1 ENSG00000206172 protein_coding 5,067.4 108,934
5 MT-CO2 ENSG00000198712 protein_coding 4,927.1 42,121
6 FTL ENSG00000087086 protein_coding 4,660.1 50,730
7 MT-ATP6 ENSG00000198899 protein_coding 4,601.3 39,163
8 MT-CO3 ENSG00000198938 protein_coding 4,002.8 39,222
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,926.5 6,625
10 MT-ND1 ENSG00000198888 protein_coding 3,750.7 44,815

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,421.4
bar=donor   line=cohort median 		1,223.7 1,385.4 51.6%
2 S100A9 protein_coding 7,920.3
bar=donor   line=cohort median 		7,732.1 9,235.1 40.2%
3 IL1B protein_coding 4.3
bar=donor   line=cohort median 		4.9 6.1 31.9%
4 CXCL8 protein_coding 125.6
bar=donor   line=cohort median 		197.4 207.4 26.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 9.2
bar=donor   line=cohort median 		2.9 2.4 94.0%
6 FCGR3B protein_coding 94.3
bar=donor   line=cohort median 		108.9 129.3 31.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 447.7
bar=donor   line=cohort median 		581.4 706.2 21.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.9
bar=donor   line=cohort median 		51.6 56.4 41.7%
9 CD3E protein_coding 33.6
bar=donor   line=cohort median 		38.1 37.7 36.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.0 3.1 60.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 216.4
bar=donor   line=cohort median 		252.2 281.6 28.2%
12 GNLY protein_coding 51.8
bar=donor   line=cohort median 		58.9 70.7 29.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,754.9
bar=donor   line=cohort median 		585.0 582.1 88.3%
14 HBA1 protein_coding 5,067.4
bar=donor   line=cohort median 		1,960.4 1,960.7 78.5%
15 HBA2 protein_coding 3,276.3
bar=donor   line=cohort median 		1,080.5 1,083.5 83.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,134.8
bar=donor   line=cohort median 		6,740.9 6,938.4 32.4%
17 MT-CO2 protein_coding 4,927.1
bar=donor   line=cohort median 		5,693.7 5,810.8 25.1%
18 MT-ND1 protein_coding 3,750.7
bar=donor   line=cohort median 		3,876.8 3,718.2 51.0%
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