GSM6881395

Dataset: gse221521 • Sample: DR group R_JS004 • Status: Diabetic retinopathy
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Quality Control Metrics

12,683,592 Total counts Group median: 12,498,211 • 52.1%ile (≈ Median)
28,584 Detected genes Group median: 27,368 • 95.1%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 60.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

62.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.13
bar=donor   line=cohort median 		0.17 40.2%
FOXO3 Insulin/IGF-1 Signaling 16.22
bar=donor   line=cohort median 		12.92 73.8%
CETP Lipid Metabolism 0.35
bar=donor   line=cohort median 		0.40 39.1%
SIRT6 Sirtuin Family 3.01
bar=donor   line=cohort median 		3.67 18.9%
SIRT1 Sirtuin Family 3.75
bar=donor   line=cohort median 		3.48 64.0%
SIRT3 Sirtuin Family 1.30
bar=donor   line=cohort median 		1.10 79.0%
IGF1R Insulin/IGF-1 Signaling 6.06
bar=donor   line=cohort median 		4.33 78.5%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 60.4%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.11
bar=donor   line=cohort median 		0.07 74.9%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 44.3%
IRS2 Insulin/IGF-1 Signaling 64.84
bar=donor   line=cohort median 		35.28 85.2%
TP53 Tumor Suppression 4.74
bar=donor   line=cohort median 		3.83 72.8%
SHC1 Signal Transduction 9.22
bar=donor   line=cohort median 		8.77 64.0%
ACE Signal Transduction 0.77
bar=donor   line=cohort median 		0.39 89.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 9,264.5 181,196
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,239.2 162,920
3 MT-CO3 ENSG00000198938 protein_coding 6,045.7 60,118
4 MT-CO2 ENSG00000198712 protein_coding 6,007.3 52,117
5 MT-RNR1 ENSG00000211459 Mt_rRNA 5,352.4 64,765
6 S100A9 ENSG00000163220 protein_coding 4,414.2 32,081
7 MT-ND4 ENSG00000198886 protein_coding 3,991.1 69,756
8 MT-ND1 ENSG00000198888 protein_coding 3,890.5 47,174
9 FTL ENSG00000087086 protein_coding 3,861.9 42,664
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,860.3 6,610

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 360.7
bar=donor   line=cohort median 		1,223.7 1,385.4 2.3%
2 S100A9 protein_coding 4,414.2
bar=donor   line=cohort median 		7,732.1 9,235.1 12.7%
3 IL1B protein_coding 3.3
bar=donor   line=cohort median 		4.9 6.1 19.4%
4 CXCL8 protein_coding 121.5
bar=donor   line=cohort median 		197.4 207.4 25.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 0.8
bar=donor   line=cohort median 		2.9 2.4 11.1%
6 FCGR3B protein_coding 44.5
bar=donor   line=cohort median 		108.9 129.3 9.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,648.5
bar=donor   line=cohort median 		581.4 706.2 94.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 51.6
bar=donor   line=cohort median 		51.6 56.4 44.3%
9 CD3E protein_coding 38.1
bar=donor   line=cohort median 		38.1 37.7 51.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.0 3.1 69.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 321.3
bar=donor   line=cohort median 		252.2 281.6 61.4%
12 GNLY protein_coding 51.5
bar=donor   line=cohort median 		58.9 70.7 28.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 496.2
bar=donor   line=cohort median 		585.0 582.1 44.8%
14 HBA1 protein_coding 1,602.6
bar=donor   line=cohort median 		1,960.4 1,960.7 40.7%
15 HBA2 protein_coding 1,197.0
bar=donor   line=cohort median 		1,080.5 1,083.5 55.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,264.5
bar=donor   line=cohort median 		6,740.9 6,938.4 86.8%
17 MT-CO2 protein_coding 6,007.3
bar=donor   line=cohort median 		5,693.7 5,810.8 52.6%
18 MT-ND1 protein_coding 3,890.5
bar=donor   line=cohort median 		3,876.8 3,718.2 56.2%
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