GSM6881396

Dataset: gse221521 • Sample: DR group R_JS005 • Status: Diabetic retinopathy
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Quality Control Metrics

12,121,546 Total counts Group median: 12,498,211 • 32.9%ile (≈ Median)
27,798 Detected genes Group median: 27,368 • 83.7%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 23.1%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

58.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.02
bar=donor   line=cohort median 		0.17 11.7%
FOXO3 Insulin/IGF-1 Signaling 17.84
bar=donor   line=cohort median 		12.92 83.7%
CETP Lipid Metabolism 0.53
bar=donor   line=cohort median 		0.40 71.2%
SIRT6 Sirtuin Family 3.54
bar=donor   line=cohort median 		3.67 41.7%
SIRT1 Sirtuin Family 3.03
bar=donor   line=cohort median 		3.48 27.7%
SIRT3 Sirtuin Family 1.09
bar=donor   line=cohort median 		1.10 49.5%
IGF1R Insulin/IGF-1 Signaling 11.40
bar=donor   line=cohort median 		4.33 98.7%
KLOTHO Anti-aging 0.15
bar=donor   line=cohort median 		0.06 88.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 69.7%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 52.98
bar=donor   line=cohort median 		35.28 75.4%
TP53 Tumor Suppression 2.91
bar=donor   line=cohort median 		3.83 17.9%
SHC1 Signal Transduction 9.75
bar=donor   line=cohort median 		8.77 82.6%
ACE Signal Transduction 0.92
bar=donor   line=cohort median 		0.39 93.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 8,103.1 56,281
2 MT-RNR2 ENSG00000210082 Mt_rRNA 7,600.4 143,629
3 MT-CO1 ENSG00000198804 protein_coding 6,045.4 112,998
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,932.8 8,072
5 MT-CO2 ENSG00000198712 protein_coding 4,550.2 37,726
6 MT-RNR1 ENSG00000211459 Mt_rRNA 4,483.8 51,850
7 MT-CO3 ENSG00000198938 protein_coding 4,143.6 39,378
8 FTL ENSG00000087086 protein_coding 3,823.3 40,366
9 MT-ND1 ENSG00000198888 protein_coding 3,516.2 40,746
10 DUSP1 ENSG00000120129 protein_coding 2,792.1 68,130

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,221.8
bar=donor   line=cohort median 		1,223.7 1,385.4 38.1%
2 S100A9 protein_coding 8,103.1
bar=donor   line=cohort median 		7,732.1 9,235.1 40.7%
3 IL1B protein_coding 4.8
bar=donor   line=cohort median 		4.9 6.1 37.6%
4 CXCL8 protein_coding 273.2
bar=donor   line=cohort median 		197.4 207.4 61.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 4.3
bar=donor   line=cohort median 		2.9 2.4 79.0%
6 FCGR3B protein_coding 209.1
bar=donor   line=cohort median 		108.9 129.3 79.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 508.2
bar=donor   line=cohort median 		581.4 706.2 29.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 39.5
bar=donor   line=cohort median 		51.6 56.4 22.5%
9 CD3E protein_coding 26.6
bar=donor   line=cohort median 		38.1 37.7 17.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.0
bar=donor   line=cohort median 		3.0 3.1 19.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 220.7
bar=donor   line=cohort median 		252.2 281.6 29.3%
12 GNLY protein_coding 55.3
bar=donor   line=cohort median 		58.9 70.7 32.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 508.9
bar=donor   line=cohort median 		585.0 582.1 46.4%
14 HBA1 protein_coding 1,873.7
bar=donor   line=cohort median 		1,960.4 1,960.7 47.4%
15 HBA2 protein_coding 1,228.9
bar=donor   line=cohort median 		1,080.5 1,083.5 58.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,045.4
bar=donor   line=cohort median 		6,740.9 6,938.4 31.9%
17 MT-CO2 protein_coding 4,550.2
bar=donor   line=cohort median 		5,693.7 5,810.8 16.8%
18 MT-ND1 protein_coding 3,516.2
bar=donor   line=cohort median 		3,876.8 3,718.2 42.2%
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