GSM6881397

Dataset: gse221521 • Sample: DR group R_JS006 • Status: Diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

12,005,556 Total counts Group median: 12,498,211 • 26.7%ile (≈ Median)
27,922 Detected genes Group median: 27,368 • 86.8%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 42.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

59.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.22
bar=donor   line=cohort median 		0.17 67.6%
FOXO3 Insulin/IGF-1 Signaling 13.51
bar=donor   line=cohort median 		12.92 54.7%
CETP Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.40 21.5%
SIRT6 Sirtuin Family 4.32
bar=donor   line=cohort median 		3.67 79.5%
SIRT1 Sirtuin Family 3.61
bar=donor   line=cohort median 		3.48 58.8%
SIRT3 Sirtuin Family 1.04
bar=donor   line=cohort median 		1.10 39.1%
IGF1R Insulin/IGF-1 Signaling 3.63
bar=donor   line=cohort median 		4.33 42.2%
KLOTHO Anti-aging 0.10
bar=donor   line=cohort median 		0.06 72.3%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.12
bar=donor   line=cohort median 		0.07 77.5%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 82.1%
IRS2 Insulin/IGF-1 Signaling 47.99
bar=donor   line=cohort median 		35.28 69.2%
TP53 Tumor Suppression 3.99
bar=donor   line=cohort median 		3.83 55.7%
SHC1 Signal Transduction 8.62
bar=donor   line=cohort median 		8.77 45.3%
ACE Signal Transduction 0.61
bar=donor   line=cohort median 		0.39 82.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,627.9 66,232
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,361.6 175,218
3 MT-CO1 ENSG00000198804 protein_coding 6,233.4 115,396
4 MT-CO3 ENSG00000198938 protein_coding 5,666.3 53,333
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,269.2 8,540
6 MT-CO2 ENSG00000198712 protein_coding 5,147.3 42,269
7 FTL ENSG00000087086 protein_coding 4,512.4 47,185
8 MT-RNR1 ENSG00000211459 Mt_rRNA 4,419.0 50,612
9 MT-ND1 ENSG00000198888 protein_coding 3,907.0 44,842
10 EEF1A1P5 ENSG00000196205 processed_pseudogene 3,432.4 57,237

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,036.0
bar=donor   line=cohort median 		1,223.7 1,385.4 24.6%
2 S100A9 protein_coding 9,627.9
bar=donor   line=cohort median 		7,732.1 9,235.1 53.1%
3 IL1B protein_coding 4.6
bar=donor   line=cohort median 		4.9 6.1 36.5%
4 CXCL8 protein_coding 89.1
bar=donor   line=cohort median 		197.4 207.4 17.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.7
bar=donor   line=cohort median 		2.9 2.4 86.3%
6 FCGR3B protein_coding 73.9
bar=donor   line=cohort median 		108.9 129.3 19.4%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 906.2
bar=donor   line=cohort median 		581.4 706.2 67.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 54.3
bar=donor   line=cohort median 		51.6 56.4 46.9%
9 CD3E protein_coding 37.0
bar=donor   line=cohort median 		38.1 37.7 47.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.9
bar=donor   line=cohort median 		3.0 3.1 68.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 249.0
bar=donor   line=cohort median 		252.2 281.6 40.2%
12 GNLY protein_coding 45.5
bar=donor   line=cohort median 		58.9 70.7 22.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 583.7
bar=donor   line=cohort median 		585.0 582.1 50.5%
14 HBA1 protein_coding 1,960.4
bar=donor   line=cohort median 		1,960.4 1,960.7 49.5%
15 HBA2 protein_coding 1,386.7
bar=donor   line=cohort median 		1,080.5 1,083.5 62.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,233.4
bar=donor   line=cohort median 		6,740.9 6,938.4 35.5%
17 MT-CO2 protein_coding 5,147.3
bar=donor   line=cohort median 		5,693.7 5,810.8 31.9%
18 MT-ND1 protein_coding 3,907.0
bar=donor   line=cohort median 		3,876.8 3,718.2 56.7%
◂ Previous Donor Back to Donor List Next Donor ▸