GSM6881398

Dataset: gse221521 • Sample: DR group R_JS007 • Status: Diabetic retinopathy
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Quality Control Metrics

13,193,089 Total counts Group median: 12,498,211 • 69.2%ile (≈ Median)
27,646 Detected genes Group median: 27,368 • 80.6%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 55.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

62.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.38
bar=donor   line=cohort median 		0.17 93.5%
FOXO3 Insulin/IGF-1 Signaling 13.36
bar=donor   line=cohort median 		12.92 53.6%
CETP Lipid Metabolism 0.36
bar=donor   line=cohort median 		0.40 40.7%
SIRT6 Sirtuin Family 4.08
bar=donor   line=cohort median 		3.67 70.2%
SIRT1 Sirtuin Family 4.42
bar=donor   line=cohort median 		3.48 80.6%
SIRT3 Sirtuin Family 1.44
bar=donor   line=cohort median 		1.10 90.4%
IGF1R Insulin/IGF-1 Signaling 5.03
bar=donor   line=cohort median 		4.33 63.0%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 25.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 28.2%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 41.7%
IRS2 Insulin/IGF-1 Signaling 56.10
bar=donor   line=cohort median 		35.28 77.5%
TP53 Tumor Suppression 5.73
bar=donor   line=cohort median 		3.83 89.9%
SHC1 Signal Transduction 9.23
bar=donor   line=cohort median 		8.77 64.5%
ACE Signal Transduction 0.50
bar=donor   line=cohort median 		0.39 69.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 8,507.6 173,076
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,372.3 172,201
3 S100A9 ENSG00000163220 protein_coding 7,215.0 54,543
4 MT-CO2 ENSG00000198712 protein_coding 6,220.1 56,131
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,677.5 10,112
6 MT-CO3 ENSG00000198938 protein_coding 5,532.7 57,227
7 MT-RNR1 ENSG00000211459 Mt_rRNA 5,068.6 63,794
8 FTL ENSG00000087086 protein_coding 4,450.4 51,140
9 MT-ND1 ENSG00000198888 protein_coding 4,276.1 53,933
10 MT-ND4 ENSG00000198886 protein_coding 3,876.4 70,473

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,183.8
bar=donor   line=cohort median 		1,223.7 1,385.4 36.5%
2 S100A9 protein_coding 7,215.0
bar=donor   line=cohort median 		7,732.1 9,235.1 33.9%
3 IL1B protein_coding 3.0
bar=donor   line=cohort median 		4.9 6.1 16.3%
4 CXCL8 protein_coding 98.6
bar=donor   line=cohort median 		197.4 207.4 18.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.7
bar=donor   line=cohort median 		2.9 2.4 73.8%
6 FCGR3B protein_coding 22.8
bar=donor   line=cohort median 		108.9 129.3 3.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,089.3
bar=donor   line=cohort median 		581.4 706.2 78.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 53.6
bar=donor   line=cohort median 		51.6 56.4 46.4%
9 CD3E protein_coding 45.5
bar=donor   line=cohort median 		38.1 37.7 70.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.0 3.1 47.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 423.5
bar=donor   line=cohort median 		252.2 281.6 80.6%
12 GNLY protein_coding 137.2
bar=donor   line=cohort median 		58.9 70.7 87.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 415.9
bar=donor   line=cohort median 		585.0 582.1 37.0%
14 HBA1 protein_coding 1,105.0
bar=donor   line=cohort median 		1,960.4 1,960.7 31.3%
15 HBA2 protein_coding 758.6
bar=donor   line=cohort median 		1,080.5 1,083.5 36.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,507.6
bar=donor   line=cohort median 		6,740.9 6,938.4 77.5%
17 MT-CO2 protein_coding 6,220.1
bar=donor   line=cohort median 		5,693.7 5,810.8 59.8%
18 MT-ND1 protein_coding 4,276.1
bar=donor   line=cohort median 		3,876.8 3,718.2 67.6%
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