GSM6881400

Dataset: gse221521 • Sample: DR group R_JS008 • Status: Diabetic retinopathy
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Quality Control Metrics

11,656,753 Total counts Group median: 12,498,211 • 17.9%ile (↓ Low)
27,927 Detected genes Group median: 27,368 • 87.3%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 21.0%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

58.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.16
bar=donor   line=cohort median 		0.17 47.9%
FOXO3 Insulin/IGF-1 Signaling 18.67
bar=donor   line=cohort median 		12.92 89.9%
CETP Lipid Metabolism 0.59
bar=donor   line=cohort median 		0.40 81.1%
SIRT6 Sirtuin Family 4.04
bar=donor   line=cohort median 		3.67 68.7%
SIRT1 Sirtuin Family 3.25
bar=donor   line=cohort median 		3.48 38.1%
SIRT3 Sirtuin Family 0.97
bar=donor   line=cohort median 		1.10 27.2%
IGF1R Insulin/IGF-1 Signaling 3.13
bar=donor   line=cohort median 		4.33 35.5%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 50.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 60.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 76.37
bar=donor   line=cohort median 		35.28 92.5%
TP53 Tumor Suppression 4.72
bar=donor   line=cohort median 		3.83 71.8%
SHC1 Signal Transduction 10.10
bar=donor   line=cohort median 		8.77 88.9%
ACE Signal Transduction 0.40
bar=donor   line=cohort median 		0.39 52.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 6,373.2 115,820
2 S100A9 ENSG00000163220 protein_coding 5,868.9 39,200
3 MT-CO1 ENSG00000198804 protein_coding 5,863.2 105,390
4 MT-CO2 ENSG00000198712 protein_coding 4,987.4 39,766
5 FTL ENSG00000087086 protein_coding 4,306.6 43,725
6 MT-CO3 ENSG00000198938 protein_coding 3,824.6 34,953
7 MT-ND1 ENSG00000198888 protein_coding 3,596.2 40,075
8 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,451.2 5,431
9 MT-ND3 ENSG00000198840 protein_coding 3,442.6 13,885
10 MT-ND4 ENSG00000198886 protein_coding 3,134.5 50,350

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,028.6
bar=donor   line=cohort median 		1,223.7 1,385.4 24.1%
2 S100A9 protein_coding 5,868.9
bar=donor   line=cohort median 		7,732.1 9,235.1 19.9%
3 IL1B protein_coding 9.3
bar=donor   line=cohort median 		4.9 6.1 73.8%
4 CXCL8 protein_coding 203.0
bar=donor   line=cohort median 		197.4 207.4 49.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.2
bar=donor   line=cohort median 		2.9 2.4 68.1%
6 FCGR3B protein_coding 124.1
bar=donor   line=cohort median 		108.9 129.3 45.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 552.6
bar=donor   line=cohort median 		581.4 706.2 33.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 33.3
bar=donor   line=cohort median 		51.6 56.4 11.7%
9 CD3E protein_coding 25.2
bar=donor   line=cohort median 		38.1 37.7 14.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.9
bar=donor   line=cohort median 		3.0 3.1 43.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 236.2
bar=donor   line=cohort median 		252.2 281.6 35.0%
12 GNLY protein_coding 56.7
bar=donor   line=cohort median 		58.9 70.7 34.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 256.1
bar=donor   line=cohort median 		585.0 582.1 21.5%
14 HBA1 protein_coding 688.3
bar=donor   line=cohort median 		1,960.4 1,960.7 16.3%
15 HBA2 protein_coding 389.4
bar=donor   line=cohort median 		1,080.5 1,083.5 15.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,863.2
bar=donor   line=cohort median 		6,740.9 6,938.4 28.2%
17 MT-CO2 protein_coding 4,987.4
bar=donor   line=cohort median 		5,693.7 5,810.8 27.2%
18 MT-ND1 protein_coding 3,596.2
bar=donor   line=cohort median 		3,876.8 3,718.2 44.3%
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