GSM6881401

Dataset: gse221521 • Sample: DR group R_JS009 • Status: Diabetic retinopathy
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Quality Control Metrics

10,921,741 Total counts Group median: 12,498,211 • 9.1%ile (↓ Low)
27,003 Detected genes Group median: 27,368 • 66.6%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 55.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

70.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.17 87.8%
FOXO3 Insulin/IGF-1 Signaling 12.26
bar=donor   line=cohort median 		12.92 42.2%
CETP Lipid Metabolism 0.35
bar=donor   line=cohort median 		0.40 37.6%
SIRT6 Sirtuin Family 4.00
bar=donor   line=cohort median 		3.67 66.1%
SIRT1 Sirtuin Family 3.12
bar=donor   line=cohort median 		3.48 31.9%
SIRT3 Sirtuin Family 1.23
bar=donor   line=cohort median 		1.10 64.5%
IGF1R Insulin/IGF-1 Signaling 6.69
bar=donor   line=cohort median 		4.33 85.8%
KLOTHO Anti-aging 0.18
bar=donor   line=cohort median 		0.06 93.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.15
bar=donor   line=cohort median 		0.07 83.7%
TERT Telomere Maintenance 0.12
bar=donor   line=cohort median 		0.01 99.2%
IRS2 Insulin/IGF-1 Signaling 57.99
bar=donor   line=cohort median 		35.28 80.1%
TP53 Tumor Suppression 5.71
bar=donor   line=cohort median 		3.83 88.9%
SHC1 Signal Transduction 9.72
bar=donor   line=cohort median 		8.77 82.1%
ACE Signal Transduction 0.51
bar=donor   line=cohort median 		0.39 70.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,966.3 152,670
2 MT-CO1 ENSG00000198804 protein_coding 7,898.7 133,024
3 MT-CO2 ENSG00000198712 protein_coding 6,656.1 49,724
4 S100A9 ENSG00000163220 protein_coding 6,486.4 40,593
5 FTL ENSG00000087086 protein_coding 5,525.9 52,567
6 MT-CO3 ENSG00000198938 protein_coding 5,078.1 43,482
7 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,955.8 7,307
8 MT-ND1 ENSG00000198888 protein_coding 4,204.8 43,903
9 MT-RNR1 ENSG00000211459 Mt_rRNA 4,151.5 43,256
10 MT-ND4 ENSG00000198886 protein_coding 3,836.4 57,738

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,692.9
bar=donor   line=cohort median 		1,223.7 1,385.4 61.4%
2 S100A9 protein_coding 6,486.4
bar=donor   line=cohort median 		7,732.1 9,235.1 27.7%
3 IL1B protein_coding 4.4
bar=donor   line=cohort median 		4.9 6.1 32.9%
4 CXCL8 protein_coding 182.8
bar=donor   line=cohort median 		197.4 207.4 41.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.6
bar=donor   line=cohort median 		2.9 2.4 56.2%
6 FCGR3B protein_coding 62.6
bar=donor   line=cohort median 		108.9 129.3 14.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 792.2
bar=donor   line=cohort median 		581.4 706.2 57.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 51.4
bar=donor   line=cohort median 		51.6 56.4 43.3%
9 CD3E protein_coding 32.5
bar=donor   line=cohort median 		38.1 37.7 32.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.1
bar=donor   line=cohort median 		3.0 3.1 21.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 141.0
bar=donor   line=cohort median 		252.2 281.6 11.1%
12 GNLY protein_coding 20.3
bar=donor   line=cohort median 		58.9 70.7 2.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 465.3
bar=donor   line=cohort median 		585.0 582.1 41.2%
14 HBA1 protein_coding 2,262.6
bar=donor   line=cohort median 		1,960.4 1,960.7 55.7%
15 HBA2 protein_coding 1,093.4
bar=donor   line=cohort median 		1,080.5 1,083.5 50.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,898.7
bar=donor   line=cohort median 		6,740.9 6,938.4 63.5%
17 MT-CO2 protein_coding 6,656.1
bar=donor   line=cohort median 		5,693.7 5,810.8 66.6%
18 MT-ND1 protein_coding 4,204.8
bar=donor   line=cohort median 		3,876.8 3,718.2 65.0%
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