GSM6881402

Dataset: gse221521 • Sample: DR group R_JS010 • Status: Diabetic retinopathy
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Quality Control Metrics

14,809,891 Total counts Group median: 12,498,211 • 90.4%ile (↑ High)
27,752 Detected genes Group median: 27,368 • 83.2%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 45.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

60.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 66.1%
FOXO3 Insulin/IGF-1 Signaling 20.63
bar=donor   line=cohort median 		12.92 97.2%
CETP Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.40 15.3%
SIRT6 Sirtuin Family 2.78
bar=donor   line=cohort median 		3.67 11.7%
SIRT1 Sirtuin Family 4.72
bar=donor   line=cohort median 		3.48 85.2%
SIRT3 Sirtuin Family 1.23
bar=donor   line=cohort median 		1.10 65.0%
IGF1R Insulin/IGF-1 Signaling 7.18
bar=donor   line=cohort median 		4.33 89.4%
KLOTHO Anti-aging 0.29
bar=donor   line=cohort median 		0.06 99.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 57.8%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 51.0%
IRS2 Insulin/IGF-1 Signaling 78.57
bar=donor   line=cohort median 		35.28 93.0%
TP53 Tumor Suppression 3.19
bar=donor   line=cohort median 		3.83 27.2%
SHC1 Signal Transduction 7.92
bar=donor   line=cohort median 		8.77 18.9%
ACE Signal Transduction 0.62
bar=donor   line=cohort median 		0.39 83.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 8,249.3 70,004
2 MT-CO1 ENSG00000198804 protein_coding 7,549.2 172,399
3 MT-RNR2 ENSG00000210082 Mt_rRNA 6,257.4 144,475
4 MT-ATP6 ENSG00000198899 protein_coding 5,916.2 59,668
5 MT-CO2 ENSG00000198712 protein_coding 5,722.8 57,972
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,091.2 10,179
7 MT-ND4 ENSG00000198886 protein_coding 4,243.5 86,602
8 MT-CO3 ENSG00000198938 protein_coding 4,205.1 48,825
9 MT-ATP8 ENSG00000228253 protein_coding 3,918.9 12,014
10 MT-ND1 ENSG00000198888 protein_coding 3,811.5 53,964

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,013.5
bar=donor   line=cohort median 		1,223.7 1,385.4 76.4%
2 S100A9 protein_coding 8,249.3
bar=donor   line=cohort median 		7,732.1 9,235.1 42.7%
3 IL1B protein_coding 4.8
bar=donor   line=cohort median 		4.9 6.1 39.1%
4 CXCL8 protein_coding 432.2
bar=donor   line=cohort median 		197.4 207.4 85.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.7
bar=donor   line=cohort median 		2.9 2.4 35.0%
6 FCGR3B protein_coding 151.3
bar=donor   line=cohort median 		108.9 129.3 58.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 530.0
bar=donor   line=cohort median 		581.4 706.2 32.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 28.8
bar=donor   line=cohort median 		51.6 56.4 7.0%
9 CD3E protein_coding 39.0
bar=donor   line=cohort median 		38.1 37.7 54.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.0 3.1 56.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 136.4
bar=donor   line=cohort median 		252.2 281.6 9.1%
12 GNLY protein_coding 38.2
bar=donor   line=cohort median 		58.9 70.7 13.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 188.0
bar=donor   line=cohort median 		585.0 582.1 12.7%
14 HBA1 protein_coding 1,075.0
bar=donor   line=cohort median 		1,960.4 1,960.7 30.8%
15 HBA2 protein_coding 437.2
bar=donor   line=cohort median 		1,080.5 1,083.5 19.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,549.2
bar=donor   line=cohort median 		6,740.9 6,938.4 59.8%
17 MT-CO2 protein_coding 5,722.8
bar=donor   line=cohort median 		5,693.7 5,810.8 47.9%
18 MT-ND1 protein_coding 3,811.5
bar=donor   line=cohort median 		3,876.8 3,718.2 53.1%
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