GSM6881403

Dataset: gse221521 • Sample: DR group R_JS011 • Status: Diabetic retinopathy
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Quality Control Metrics

18,244,928 Total counts Group median: 12,498,211 • 97.2%ile (↑ High)
28,339 Detected genes Group median: 27,368 • 92.0%ile (↑ High)
4 Mitochondrial fraction (%) Group median: 6 • 14.2%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

63.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.17 80.6%
FOXO3 Insulin/IGF-1 Signaling 18.65
bar=donor   line=cohort median 		12.92 89.4%
CETP Lipid Metabolism 0.85
bar=donor   line=cohort median 		0.40 94.0%
SIRT6 Sirtuin Family 2.90
bar=donor   line=cohort median 		3.67 16.3%
SIRT1 Sirtuin Family 5.41
bar=donor   line=cohort median 		3.48 94.0%
SIRT3 Sirtuin Family 1.25
bar=donor   line=cohort median 		1.10 68.7%
IGF1R Insulin/IGF-1 Signaling 5.89
bar=donor   line=cohort median 		4.33 76.4%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 34.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.15
bar=donor   line=cohort median 		0.07 84.2%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 58.8%
IRS2 Insulin/IGF-1 Signaling 41.89
bar=donor   line=cohort median 		35.28 59.8%
TP53 Tumor Suppression 5.40
bar=donor   line=cohort median 		3.83 84.2%
SHC1 Signal Transduction 8.86
bar=donor   line=cohort median 		8.77 53.6%
ACE Signal Transduction 0.19
bar=donor   line=cohort median 		0.39 13.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 6,187.4 174,075
2 MT-ATP6 ENSG00000198899 protein_coding 4,727.6 58,739
3 MT-RNR2 ENSG00000210082 Mt_rRNA 4,662.8 132,627
4 MT-CO2 ENSG00000198712 protein_coding 4,419.5 55,153
5 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,287.7 10,561
6 MT-ATP8 ENSG00000228253 protein_coding 3,448.8 13,025
7 MT-ND4 ENSG00000198886 protein_coding 3,251.2 81,740
8 FTL ENSG00000087086 protein_coding 3,131.9 49,770
9 MT-ND4L ENSG00000212907 protein_coding 2,897.2 15,699
10 S100A9 ENSG00000163220 protein_coding 2,735.7 28,600

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 538.2
bar=donor   line=cohort median 		1,223.7 1,385.4 8.0%
2 S100A9 protein_coding 2,735.7
bar=donor   line=cohort median 		7,732.1 9,235.1 6.0%
3 IL1B protein_coding 3.9
bar=donor   line=cohort median 		4.9 6.1 26.7%
4 CXCL8 protein_coding 439.7
bar=donor   line=cohort median 		197.4 207.4 86.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 7.3
bar=donor   line=cohort median 		2.9 2.4 88.3%
6 FCGR3B protein_coding 81.2
bar=donor   line=cohort median 		108.9 129.3 24.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 605.3
bar=donor   line=cohort median 		581.4 706.2 38.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 31.1
bar=donor   line=cohort median 		51.6 56.4 9.1%
9 CD3E protein_coding 30.2
bar=donor   line=cohort median 		38.1 37.7 26.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.0 3.1 31.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 272.1
bar=donor   line=cohort median 		252.2 281.6 46.9%
12 GNLY protein_coding 57.9
bar=donor   line=cohort median 		58.9 70.7 35.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 209.7
bar=donor   line=cohort median 		585.0 582.1 15.8%
14 HBA1 protein_coding 1,123.1
bar=donor   line=cohort median 		1,960.4 1,960.7 31.9%
15 HBA2 protein_coding 267.2
bar=donor   line=cohort median 		1,080.5 1,083.5 6.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,187.4
bar=donor   line=cohort median 		6,740.9 6,938.4 33.4%
17 MT-CO2 protein_coding 4,419.5
bar=donor   line=cohort median 		5,693.7 5,810.8 16.3%
18 MT-ND1 protein_coding 2,610.9
bar=donor   line=cohort median 		3,876.8 3,718.2 16.8%
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