GSM6881404

Dataset: gse221521 • Sample: DR group R_JS012 • Status: Diabetic retinopathy
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Quality Control Metrics

11,889,831 Total counts Group median: 12,498,211 • 23.1%ile (↓ Low)
27,812 Detected genes Group median: 27,368 • 84.2%ile (↑ High)
7 Mitochondrial fraction (%) Group median: 6 • 65.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

61.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.25
bar=donor   line=cohort median 		0.17 73.3%
FOXO3 Insulin/IGF-1 Signaling 19.63
bar=donor   line=cohort median 		12.92 93.5%
CETP Lipid Metabolism 0.46
bar=donor   line=cohort median 		0.40 63.0%
SIRT6 Sirtuin Family 3.06
bar=donor   line=cohort median 		3.67 20.0%
SIRT1 Sirtuin Family 5.10
bar=donor   line=cohort median 		3.48 89.4%
SIRT3 Sirtuin Family 1.11
bar=donor   line=cohort median 		1.10 52.1%
IGF1R Insulin/IGF-1 Signaling 4.82
bar=donor   line=cohort median 		4.33 58.3%
KLOTHO Anti-aging 0.01
bar=donor   line=cohort median 		0.06 16.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.20
bar=donor   line=cohort median 		0.07 87.8%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 72.8%
IRS2 Insulin/IGF-1 Signaling 32.19
bar=donor   line=cohort median 		35.28 44.3%
TP53 Tumor Suppression 4.93
bar=donor   line=cohort median 		3.83 76.9%
SHC1 Signal Transduction 11.14
bar=donor   line=cohort median 		8.77 97.2%
ACE Signal Transduction 0.23
bar=donor   line=cohort median 		0.39 21.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-CO1 ENSG00000198804 protein_coding 9,743.3 178,635
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,859.6 127,151
3 MT-ATP6 ENSG00000198899 protein_coding 6,451.2 52,235
4 MT-CO2 ENSG00000198712 protein_coding 6,014.3 48,912
5 MT-CO3 ENSG00000198938 protein_coding 4,844.3 45,157
6 MT-ATP8 ENSG00000228253 protein_coding 4,569.3 11,246
7 MT-ND4 ENSG00000198886 protein_coding 4,502.6 73,771
8 MT-ND4L ENSG00000212907 protein_coding 4,372.4 15,440
9 MT-ND1 ENSG00000198888 protein_coding 4,122.9 46,864
10 S100A9 ENSG00000163220 protein_coding 4,115.9 28,041

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 721.3
bar=donor   line=cohort median 		1,223.7 1,385.4 12.2%
2 S100A9 protein_coding 4,115.9
bar=donor   line=cohort median 		7,732.1 9,235.1 11.7%
3 IL1B protein_coding 3.7
bar=donor   line=cohort median 		4.9 6.1 23.6%
4 CXCL8 protein_coding 197.7
bar=donor   line=cohort median 		197.4 207.4 46.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 5.4
bar=donor   line=cohort median 		2.9 2.4 82.6%
6 FCGR3B protein_coding 92.4
bar=donor   line=cohort median 		108.9 129.3 30.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 283.4
bar=donor   line=cohort median 		581.4 706.2 9.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 72.2
bar=donor   line=cohort median 		51.6 56.4 69.2%
9 CD3E protein_coding 43.4
bar=donor   line=cohort median 		38.1 37.7 65.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.1
bar=donor   line=cohort median 		3.0 3.1 72.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 263.2
bar=donor   line=cohort median 		252.2 281.6 43.3%
12 GNLY protein_coding 158.6
bar=donor   line=cohort median 		58.9 70.7 90.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 457.6
bar=donor   line=cohort median 		585.0 582.1 39.6%
14 HBA1 protein_coding 2,061.4
bar=donor   line=cohort median 		1,960.4 1,960.7 51.6%
15 HBA2 protein_coding 589.0
bar=donor   line=cohort median 		1,080.5 1,083.5 28.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,743.3
bar=donor   line=cohort median 		6,740.9 6,938.4 90.9%
17 MT-CO2 protein_coding 6,014.3
bar=donor   line=cohort median 		5,693.7 5,810.8 53.1%
18 MT-ND1 protein_coding 4,122.9
bar=donor   line=cohort median 		3,876.8 3,718.2 61.9%
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