GSM6881406

Dataset: gse221521 • Sample: DR group R_JS013 • Status: Diabetic retinopathy
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Quality Control Metrics

15,163,772 Total counts Group median: 12,498,211 • 92.5%ile (↑ High)
25,842 Detected genes Group median: 27,368 • 29.3%ile (≈ Median)
10 Mitochondrial fraction (%) Group median: 6 • 92.5%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 32.9%
FOXO3 Insulin/IGF-1 Signaling 11.19
bar=donor   line=cohort median 		12.92 31.9%
CETP Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.40 36.5%
SIRT6 Sirtuin Family 4.09
bar=donor   line=cohort median 		3.67 71.8%
SIRT1 Sirtuin Family 3.43
bar=donor   line=cohort median 		3.48 44.3%
SIRT3 Sirtuin Family 0.94
bar=donor   line=cohort median 		1.10 21.5%
IGF1R Insulin/IGF-1 Signaling 5.03
bar=donor   line=cohort median 		4.33 62.4%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 57.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.09
bar=donor   line=cohort median 		0.07 64.0%
TERT Telomere Maintenance 0.01
bar=donor   line=cohort median 		0.01 39.1%
IRS2 Insulin/IGF-1 Signaling 29.24
bar=donor   line=cohort median 		35.28 39.6%
TP53 Tumor Suppression 6.84
bar=donor   line=cohort median 		3.83 98.7%
SHC1 Signal Transduction 10.04
bar=donor   line=cohort median 		8.77 86.3%
ACE Signal Transduction 0.49
bar=donor   line=cohort median 		0.39 66.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 13,869.0 327,868
2 MT-CO1 ENSG00000198804 protein_coding 11,167.9 261,133
3 MT-CO2 ENSG00000198712 protein_coding 10,604.3 109,988
4 MT-CO3 ENSG00000198938 protein_coding 8,764.5 104,196
5 MT-ATP8 ENSG00000228253 protein_coding 6,903.4 21,669
6 S100A9 ENSG00000163220 protein_coding 6,471.3 56,228
7 MT-ND1 ENSG00000198888 protein_coding 6,255.1 90,677
8 MT-RNR1 ENSG00000211459 Mt_rRNA 6,077.9 87,924
9 MT-ND4 ENSG00000198886 protein_coding 6,044.8 126,311
10 FTL ENSG00000087086 protein_coding 5,572.2 73,596

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 775.0
bar=donor   line=cohort median 		1,223.7 1,385.4 13.7%
2 S100A9 protein_coding 6,471.3
bar=donor   line=cohort median 		7,732.1 9,235.1 26.7%
3 IL1B protein_coding 4.5
bar=donor   line=cohort median 		4.9 6.1 34.5%
4 CXCL8 protein_coding 207.4
bar=donor   line=cohort median 		197.4 207.4 50.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 7.8
bar=donor   line=cohort median 		2.9 2.4 89.9%
6 FCGR3B protein_coding 108.9
bar=donor   line=cohort median 		108.9 129.3 38.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 741.2
bar=donor   line=cohort median 		581.4 706.2 54.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 80.8
bar=donor   line=cohort median 		51.6 56.4 76.9%
9 CD3E protein_coding 51.3
bar=donor   line=cohort median 		38.1 37.7 79.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.1
bar=donor   line=cohort median 		3.0 3.1 3.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 291.9
bar=donor   line=cohort median 		252.2 281.6 52.6%
12 GNLY protein_coding 65.3
bar=donor   line=cohort median 		58.9 70.7 40.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 377.4
bar=donor   line=cohort median 		585.0 582.1 30.8%
14 HBA1 protein_coding 1,714.9
bar=donor   line=cohort median 		1,960.4 1,960.7 43.8%
15 HBA2 protein_coding 539.7
bar=donor   line=cohort median 		1,080.5 1,083.5 25.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 11,167.9
bar=donor   line=cohort median 		6,740.9 6,938.4 95.1%
17 MT-CO2 protein_coding 10,604.3
bar=donor   line=cohort median 		5,693.7 5,810.8 94.6%
18 MT-ND1 protein_coding 6,255.1
bar=donor   line=cohort median 		3,876.8 3,718.2 91.5%
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