GSM6881407

Dataset: gse221521 • Sample: DR group R_JS014 • Status: Diabetic retinopathy
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Quality Control Metrics

21,926,479 Total counts Group median: 12,498,211 • 99.2%ile (↑ High)
27,652 Detected genes Group median: 27,368 • 81.1%ile (↑ High)
8 Mitochondrial fraction (%) Group median: 6 • 80.6%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.10
bar=donor   line=cohort median 		0.17 30.8%
FOXO3 Insulin/IGF-1 Signaling 14.66
bar=donor   line=cohort median 		12.92 61.9%
CETP Lipid Metabolism 0.28
bar=donor   line=cohort median 		0.40 22.0%
SIRT6 Sirtuin Family 3.20
bar=donor   line=cohort median 		3.67 24.1%
SIRT1 Sirtuin Family 3.69
bar=donor   line=cohort median 		3.48 63.0%
SIRT3 Sirtuin Family 0.95
bar=donor   line=cohort median 		1.10 24.1%
IGF1R Insulin/IGF-1 Signaling 3.95
bar=donor   line=cohort median 		4.33 46.4%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 66.1%
APOC3 Lipid Metabolism 0.09
bar=donor   line=cohort median 		0.00 98.2%
IL6 Inflammation 0.01
bar=donor   line=cohort median 		0.07 21.0%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 37.6%
IRS2 Insulin/IGF-1 Signaling 56.86
bar=donor   line=cohort median 		35.28 78.0%
TP53 Tumor Suppression 5.22
bar=donor   line=cohort median 		3.83 81.6%
SHC1 Signal Transduction 8.82
bar=donor   line=cohort median 		8.77 51.6%
ACE Signal Transduction 0.50
bar=donor   line=cohort median 		0.39 68.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 12,027.8 411,150
2 MT-CO1 ENSG00000198804 protein_coding 9,300.4 314,452
3 MT-CO2 ENSG00000198712 protein_coding 7,808.9 117,116
4 MT-CO3 ENSG00000198938 protein_coding 6,387.5 109,804
5 S100A9 ENSG00000163220 protein_coding 6,296.1 79,104
6 HBA1 ENSG00000206172 protein_coding 6,168.9 232,652
7 MT-ATP8 ENSG00000228253 protein_coding 5,719.2 25,958
8 MT-ND1 ENSG00000198888 protein_coding 5,249.0 110,028
9 MT-ND4 ENSG00000198886 protein_coding 4,906.0 148,233
10 FTL ENSG00000087086 protein_coding 4,899.4 93,569

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,045.4
bar=donor   line=cohort median 		1,223.7 1,385.4 26.7%
2 S100A9 protein_coding 6,296.1
bar=donor   line=cohort median 		7,732.1 9,235.1 25.6%
3 IL1B protein_coding 4.7
bar=donor   line=cohort median 		4.9 6.1 37.0%
4 CXCL8 protein_coding 303.7
bar=donor   line=cohort median 		197.4 207.4 67.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.6
bar=donor   line=cohort median 		2.9 2.4 56.7%
6 FCGR3B protein_coding 179.0
bar=donor   line=cohort median 		108.9 129.3 68.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 1,034.4
bar=donor   line=cohort median 		581.4 706.2 73.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 43.4
bar=donor   line=cohort median 		51.6 56.4 29.8%
9 CD3E protein_coding 30.5
bar=donor   line=cohort median 		38.1 37.7 27.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.2
bar=donor   line=cohort median 		3.0 3.1 24.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 155.1
bar=donor   line=cohort median 		252.2 281.6 14.2%
12 GNLY protein_coding 36.7
bar=donor   line=cohort median 		58.9 70.7 12.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,780.0
bar=donor   line=cohort median 		585.0 582.1 88.9%
14 HBA1 protein_coding 6,168.9
bar=donor   line=cohort median 		1,960.4 1,960.7 84.2%
15 HBA2 protein_coding 1,748.1
bar=donor   line=cohort median 		1,080.5 1,083.5 67.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,300.4
bar=donor   line=cohort median 		6,740.9 6,938.4 87.3%
17 MT-CO2 protein_coding 7,808.9
bar=donor   line=cohort median 		5,693.7 5,810.8 77.5%
18 MT-ND1 protein_coding 5,249.0
bar=donor   line=cohort median 		3,876.8 3,718.2 82.6%
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