GSM6881408

Dataset: gse221521 • Sample: DR group R_JS015 • Status: Diabetic retinopathy
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Quality Control Metrics

13,427,685 Total counts Group median: 12,498,211 • 75.9%ile (↑ High)
27,369 Detected genes Group median: 27,368 • 74.9%ile (≈ Median)
3 Mitochondrial fraction (%) Group median: 6 • 3.4%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

60.9Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.12
bar=donor   line=cohort median 		0.17 38.1%
FOXO3 Insulin/IGF-1 Signaling 18.64
bar=donor   line=cohort median 		12.92 88.9%
CETP Lipid Metabolism 0.32
bar=donor   line=cohort median 		0.40 31.4%
SIRT6 Sirtuin Family 3.98
bar=donor   line=cohort median 		3.67 64.0%
SIRT1 Sirtuin Family 1.84
bar=donor   line=cohort median 		3.48 1.3%
SIRT3 Sirtuin Family 1.55
bar=donor   line=cohort median 		1.10 94.6%
IGF1R Insulin/IGF-1 Signaling 14.63
bar=donor   line=cohort median 		4.33 99.7%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 79.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 27.7%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 66.1%
IRS2 Insulin/IGF-1 Signaling 84.15
bar=donor   line=cohort median 		35.28 95.1%
TP53 Tumor Suppression 3.24
bar=donor   line=cohort median 		3.83 29.8%
SHC1 Signal Transduction 10.41
bar=donor   line=cohort median 		8.77 90.9%
ACE Signal Transduction 0.43
bar=donor   line=cohort median 		0.39 57.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,940.9 114,956
2 DUSP1 ENSG00000120129 protein_coding 5,600.2 151,374
3 MT-RNR2 ENSG00000210082 Mt_rRNA 4,813.9 100,772
4 FTL ENSG00000087086 protein_coding 4,778.9 55,892
5 MT-CO1 ENSG00000198804 protein_coding 3,543.5 73,369
6 MT-ATP6 ENSG00000198899 protein_coding 3,095.3 28,304
7 MT-CO2 ENSG00000198712 protein_coding 3,053.3 28,043
8 MT-ND1 ENSG00000198888 protein_coding 2,988.9 38,368
9 S100A8 ENSG00000143546 protein_coding 2,983.5 49,877
10 MT-CO3 ENSG00000198938 protein_coding 2,476.7 26,073

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,983.5
bar=donor   line=cohort median 		1,223.7 1,385.4 94.6%
2 S100A9 protein_coding 14,940.9
bar=donor   line=cohort median 		7,732.1 9,235.1 83.7%
3 IL1B protein_coding 5.1
bar=donor   line=cohort median 		4.9 6.1 42.2%
4 CXCL8 protein_coding 47.6
bar=donor   line=cohort median 		197.4 207.4 8.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.9
bar=donor   line=cohort median 		2.9 2.4 87.3%
6 FCGR3B protein_coding 136.6
bar=donor   line=cohort median 		108.9 129.3 52.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 155.7
bar=donor   line=cohort median 		581.4 706.2 1.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 31.9
bar=donor   line=cohort median 		51.6 56.4 10.6%
9 CD3E protein_coding 21.7
bar=donor   line=cohort median 		38.1 37.7 8.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.8
bar=donor   line=cohort median 		3.0 3.1 12.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 122.1
bar=donor   line=cohort median 		252.2 281.6 6.5%
12 GNLY protein_coding 21.7
bar=donor   line=cohort median 		58.9 70.7 3.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,179.1
bar=donor   line=cohort median 		585.0 582.1 76.4%
14 HBA1 protein_coding 2,265.0
bar=donor   line=cohort median 		1,960.4 1,960.7 56.2%
15 HBA2 protein_coding 1,816.1
bar=donor   line=cohort median 		1,080.5 1,083.5 68.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,543.5
bar=donor   line=cohort median 		6,740.9 6,938.4 2.3%
17 MT-CO2 protein_coding 3,053.3
bar=donor   line=cohort median 		5,693.7 5,810.8 3.9%
18 MT-ND1 protein_coding 2,988.9
bar=donor   line=cohort median 		3,876.8 3,718.2 24.6%
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