GSM6881409

Dataset: gse221521 • Sample: DR group R_JS016 • Status: Diabetic retinopathy
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Quality Control Metrics

14,286,326 Total counts Group median: 12,498,211 • 85.2%ile (↑ High)
28,503 Detected genes Group median: 27,368 • 94.6%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 16.8%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

53.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.17 50.0%
FOXO3 Insulin/IGF-1 Signaling 20.54
bar=donor   line=cohort median 		12.92 96.6%
CETP Lipid Metabolism 0.23
bar=donor   line=cohort median 		0.40 12.2%
SIRT6 Sirtuin Family 3.94
bar=donor   line=cohort median 		3.67 62.4%
SIRT1 Sirtuin Family 3.51
bar=donor   line=cohort median 		3.48 53.1%
SIRT3 Sirtuin Family 0.96
bar=donor   line=cohort median 		1.10 25.1%
IGF1R Insulin/IGF-1 Signaling 6.62
bar=donor   line=cohort median 		4.33 83.7%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 49.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 69.71
bar=donor   line=cohort median 		35.28 88.9%
TP53 Tumor Suppression 3.60
bar=donor   line=cohort median 		3.83 41.2%
SHC1 Signal Transduction 9.62
bar=donor   line=cohort median 		8.77 78.0%
ACE Signal Transduction 0.70
bar=donor   line=cohort median 		0.39 87.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,046.0 74,051
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,288.1 184,595
3 MT-CO1 ENSG00000198804 protein_coding 5,025.7 110,714
4 FTL ENSG00000087086 protein_coding 4,559.1 56,731
5 MT-RNR1 ENSG00000211459 Mt_rRNA 4,071.6 55,492
6 DUSP1 ENSG00000120129 protein_coding 3,744.9 107,698
7 MT-CO2 ENSG00000198712 protein_coding 3,617.3 35,348
8 MT-CO3 ENSG00000198938 protein_coding 3,178.6 35,602
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 3,164.9 6,104
10 MT-ND1 ENSG00000198888 protein_coding 2,995.0 40,905

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 921.4
bar=donor   line=cohort median 		1,223.7 1,385.4 19.9%
2 S100A9 protein_coding 9,046.0
bar=donor   line=cohort median 		7,732.1 9,235.1 49.0%
3 IL1B protein_coding 5.5
bar=donor   line=cohort median 		4.9 6.1 45.3%
4 CXCL8 protein_coding 234.9
bar=donor   line=cohort median 		197.4 207.4 55.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 5.3
bar=donor   line=cohort median 		2.9 2.4 82.1%
6 FCGR3B protein_coding 99.3
bar=donor   line=cohort median 		108.9 129.3 32.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 547.1
bar=donor   line=cohort median 		581.4 706.2 33.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 41.6
bar=donor   line=cohort median 		51.6 56.4 25.1%
9 CD3E protein_coding 24.3
bar=donor   line=cohort median 		38.1 37.7 12.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 0.8
bar=donor   line=cohort median 		3.0 3.1 2.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 232.4
bar=donor   line=cohort median 		252.2 281.6 33.4%
12 GNLY protein_coding 42.4
bar=donor   line=cohort median 		58.9 70.7 18.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 627.6
bar=donor   line=cohort median 		585.0 582.1 53.6%
14 HBA1 protein_coding 1,049.2
bar=donor   line=cohort median 		1,960.4 1,960.7 28.2%
15 HBA2 protein_coding 806.7
bar=donor   line=cohort median 		1,080.5 1,083.5 39.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,025.7
bar=donor   line=cohort median 		6,740.9 6,938.4 13.7%
17 MT-CO2 protein_coding 3,617.3
bar=donor   line=cohort median 		5,693.7 5,810.8 7.5%
18 MT-ND1 protein_coding 2,995.0
bar=donor   line=cohort median 		3,876.8 3,718.2 25.1%
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