GSM6881410

Dataset: gse221521 • Sample: DR group R_JS017 • Status: Diabetic retinopathy
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Quality Control Metrics

13,048,664 Total counts Group median: 12,498,211 • 64.0%ile (≈ Median)
27,860 Detected genes Group median: 27,368 • 85.8%ile (↑ High)
4 Mitochondrial fraction (%) Group median: 6 • 6.5%ile (↓ Low)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

62.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.33
bar=donor   line=cohort median 		0.17 86.3%
FOXO3 Insulin/IGF-1 Signaling 21.19
bar=donor   line=cohort median 		12.92 97.7%
CETP Lipid Metabolism 0.38
bar=donor   line=cohort median 		0.40 44.8%
SIRT6 Sirtuin Family 3.55
bar=donor   line=cohort median 		3.67 42.8%
SIRT1 Sirtuin Family 2.39
bar=donor   line=cohort median 		3.48 3.9%
SIRT3 Sirtuin Family 1.07
bar=donor   line=cohort median 		1.10 44.3%
IGF1R Insulin/IGF-1 Signaling 10.97
bar=donor   line=cohort median 		4.33 98.2%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 42.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.32
bar=donor   line=cohort median 		0.07 97.2%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 79.5%
IRS2 Insulin/IGF-1 Signaling 60.86
bar=donor   line=cohort median 		35.28 82.6%
TP53 Tumor Suppression 3.19
bar=donor   line=cohort median 		3.83 26.2%
SHC1 Signal Transduction 10.10
bar=donor   line=cohort median 		8.77 88.3%
ACE Signal Transduction 0.41
bar=donor   line=cohort median 		0.39 54.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 14,429.1 107,885
2 MT-RNR2 ENSG00000210082 Mt_rRNA 6,139.5 124,896
3 FTL ENSG00000087086 protein_coding 4,056.4 46,103
4 DUSP1 ENSG00000120129 protein_coding 3,937.6 103,428
5 MT-CO1 ENSG00000198804 protein_coding 3,843.0 77,325
6 G0S2 ENSG00000123689 protein_coding 3,666.7 41,913
7 MT-CO2 ENSG00000198712 protein_coding 3,371.3 30,090
8 MT-ATP6 ENSG00000198899 protein_coding 3,315.3 29,460
9 S100A8 ENSG00000143546 protein_coding 2,881.9 46,818
10 MT-ND3 ENSG00000198840 protein_coding 2,683.4 12,115

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,881.9
bar=donor   line=cohort median 		1,223.7 1,385.4 93.0%
2 S100A9 protein_coding 14,429.1
bar=donor   line=cohort median 		7,732.1 9,235.1 81.1%
3 IL1B protein_coding 10.7
bar=donor   line=cohort median 		4.9 6.1 81.6%
4 CXCL8 protein_coding 401.9
bar=donor   line=cohort median 		197.4 207.4 80.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.9
bar=donor   line=cohort median 		2.9 2.4 41.2%
6 FCGR3B protein_coding 78.2
bar=donor   line=cohort median 		108.9 129.3 23.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 507.4
bar=donor   line=cohort median 		581.4 706.2 29.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 37.0
bar=donor   line=cohort median 		51.6 56.4 17.9%
9 CD3E protein_coding 18.2
bar=donor   line=cohort median 		38.1 37.7 4.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.5
bar=donor   line=cohort median 		3.0 3.1 32.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 118.0
bar=donor   line=cohort median 		252.2 281.6 5.4%
12 GNLY protein_coding 27.9
bar=donor   line=cohort median 		58.9 70.7 7.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 573.4
bar=donor   line=cohort median 		585.0 582.1 49.5%
14 HBA1 protein_coding 1,755.6
bar=donor   line=cohort median 		1,960.4 1,960.7 45.3%
15 HBA2 protein_coding 1,111.1
bar=donor   line=cohort median 		1,080.5 1,083.5 52.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 3,843.0
bar=donor   line=cohort median 		6,740.9 6,938.4 4.4%
17 MT-CO2 protein_coding 3,371.3
bar=donor   line=cohort median 		5,693.7 5,810.8 4.9%
18 MT-ND1 protein_coding 2,077.8
bar=donor   line=cohort median 		3,876.8 3,718.2 8.0%
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