GSM6881411

Dataset: gse221521 • Sample: DR group R_JS018 • Status: Diabetic retinopathy
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Quality Control Metrics

11,666,716 Total counts Group median: 12,498,211 • 18.9%ile (↓ Low)
28,986 Detected genes Group median: 27,368 • 98.2%ile (↑ High)
7 Mitochondrial fraction (%) Group median: 6 • 69.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

71.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.17 88.3%
FOXO3 Insulin/IGF-1 Signaling 13.91
bar=donor   line=cohort median 		12.92 56.2%
CETP Lipid Metabolism 0.40
bar=donor   line=cohort median 		0.40 51.0%
SIRT6 Sirtuin Family 4.21
bar=donor   line=cohort median 		3.67 75.4%
SIRT1 Sirtuin Family 3.52
bar=donor   line=cohort median 		3.48 53.6%
SIRT3 Sirtuin Family 1.56
bar=donor   line=cohort median 		1.10 95.1%
IGF1R Insulin/IGF-1 Signaling 7.26
bar=donor   line=cohort median 		4.33 91.5%
KLOTHO Anti-aging 0.17
bar=donor   line=cohort median 		0.06 92.0%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.12
bar=donor   line=cohort median 		0.07 78.5%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 30.05
bar=donor   line=cohort median 		35.28 41.7%
TP53 Tumor Suppression 6.41
bar=donor   line=cohort median 		3.83 95.6%
SHC1 Signal Transduction 10.86
bar=donor   line=cohort median 		8.77 95.1%
ACE Signal Transduction 0.62
bar=donor   line=cohort median 		0.39 83.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,977.0 181,466
2 MT-CO1 ENSG00000198804 protein_coding 8,501.9 152,950
3 S100A9 ENSG00000163220 protein_coding 6,654.1 44,483
4 MT-CO2 ENSG00000198712 protein_coding 5,923.0 47,266
5 MT-RNR1 ENSG00000211459 Mt_rRNA 5,666.1 63,064
6 MT-CO3 ENSG00000198938 protein_coding 5,516.7 50,460
7 MT-ND1 ENSG00000198888 protein_coding 5,177.0 57,741
8 MT-ND3 ENSG00000198840 protein_coding 4,470.5 18,046
9 MT-ND4 ENSG00000198886 protein_coding 4,044.7 65,026
10 MT-ND2 ENSG00000198763 protein_coding 3,516.1 42,744

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,097.4
bar=donor   line=cohort median 		1,223.7 1,385.4 30.3%
2 S100A9 protein_coding 6,654.1
bar=donor   line=cohort median 		7,732.1 9,235.1 29.3%
3 IL1B protein_coding 11.9
bar=donor   line=cohort median 		4.9 6.1 83.2%
4 CXCL8 protein_coding 109.7
bar=donor   line=cohort median 		197.4 207.4 22.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.4
bar=donor   line=cohort median 		2.9 2.4 50.5%
6 FCGR3B protein_coding 81.9
bar=donor   line=cohort median 		108.9 129.3 25.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 618.3
bar=donor   line=cohort median 		581.4 706.2 41.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 59.4
bar=donor   line=cohort median 		51.6 56.4 55.2%
9 CD3E protein_coding 38.4
bar=donor   line=cohort median 		38.1 37.7 52.6%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.0 3.1 70.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 274.5
bar=donor   line=cohort median 		252.2 281.6 47.4%
12 GNLY protein_coding 51.0
bar=donor   line=cohort median 		58.9 70.7 28.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 381.0
bar=donor   line=cohort median 		585.0 582.1 31.3%
14 HBA1 protein_coding 1,579.6
bar=donor   line=cohort median 		1,960.4 1,960.7 40.2%
15 HBA2 protein_coding 1,103.0
bar=donor   line=cohort median 		1,080.5 1,083.5 51.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,501.9
bar=donor   line=cohort median 		6,740.9 6,938.4 76.9%
17 MT-CO2 protein_coding 5,923.0
bar=donor   line=cohort median 		5,693.7 5,810.8 51.6%
18 MT-ND1 protein_coding 5,177.0
bar=donor   line=cohort median 		3,876.8 3,718.2 80.6%
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