GSM6881413

Dataset: gse221521 • Sample: DR group R_JS019 • Status: Diabetic retinopathy
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Quality Control Metrics

12,004,071 Total counts Group median: 12,498,211 • 26.2%ile (≈ Median)
27,544 Detected genes Group median: 27,368 • 78.0%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 56.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

56.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.20
bar=donor   line=cohort median 		0.17 60.9%
FOXO3 Insulin/IGF-1 Signaling 14.38
bar=donor   line=cohort median 		12.92 60.4%
CETP Lipid Metabolism 0.26
bar=donor   line=cohort median 		0.40 18.9%
SIRT6 Sirtuin Family 3.86
bar=donor   line=cohort median 		3.67 59.3%
SIRT1 Sirtuin Family 4.49
bar=donor   line=cohort median 		3.48 82.6%
SIRT3 Sirtuin Family 0.90
bar=donor   line=cohort median 		1.10 20.0%
IGF1R Insulin/IGF-1 Signaling 6.66
bar=donor   line=cohort median 		4.33 84.2%
KLOTHO Anti-aging 0.25
bar=donor   line=cohort median 		0.06 97.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 50.51
bar=donor   line=cohort median 		35.28 73.8%
TP53 Tumor Suppression 5.00
bar=donor   line=cohort median 		3.83 78.5%
SHC1 Signal Transduction 11.41
bar=donor   line=cohort median 		8.77 98.7%
ACE Signal Transduction 0.31
bar=donor   line=cohort median 		0.39 37.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 9,615.6 66,139
2 MT-RNR2 ENSG00000210082 Mt_rRNA 8,605.7 161,050
3 MT-CO1 ENSG00000198804 protein_coding 7,904.6 146,317
4 MT-CO3 ENSG00000198938 protein_coding 5,875.0 55,291
5 FTL ENSG00000087086 protein_coding 5,698.3 59,579
6 MT-CO2 ENSG00000198712 protein_coding 5,586.8 45,872
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,655.4 53,313
8 MT-ND3 ENSG00000198840 protein_coding 4,580.1 19,023
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,441.1 7,197
10 MT-ND1 ENSG00000198888 protein_coding 4,170.0 47,854

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,744.1
bar=donor   line=cohort median 		1,223.7 1,385.4 65.5%
2 S100A9 protein_coding 9,615.6
bar=donor   line=cohort median 		7,732.1 9,235.1 52.6%
3 IL1B protein_coding 6.1
bar=donor   line=cohort median 		4.9 6.1 50.0%
4 CXCL8 protein_coding 303.1
bar=donor   line=cohort median 		197.4 207.4 67.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.3
bar=donor   line=cohort median 		2.9 2.4 25.1%
6 FCGR3B protein_coding 119.5
bar=donor   line=cohort median 		108.9 129.3 43.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 494.3
bar=donor   line=cohort median 		581.4 706.2 27.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 35.8
bar=donor   line=cohort median 		51.6 56.4 16.8%
9 CD3E protein_coding 17.9
bar=donor   line=cohort median 		38.1 37.7 4.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.6
bar=donor   line=cohort median 		3.0 3.1 9.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 358.9
bar=donor   line=cohort median 		252.2 281.6 70.2%
12 GNLY protein_coding 54.3
bar=donor   line=cohort median 		58.9 70.7 31.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 619.4
bar=donor   line=cohort median 		585.0 582.1 53.1%
14 HBA1 protein_coding 2,092.4
bar=donor   line=cohort median 		1,960.4 1,960.7 52.6%
15 HBA2 protein_coding 1,039.1
bar=donor   line=cohort median 		1,080.5 1,083.5 46.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,904.6
bar=donor   line=cohort median 		6,740.9 6,938.4 64.5%
17 MT-CO2 protein_coding 5,586.8
bar=donor   line=cohort median 		5,693.7 5,810.8 43.3%
18 MT-ND1 protein_coding 4,170.0
bar=donor   line=cohort median 		3,876.8 3,718.2 63.0%
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