GSM6881414

Dataset: gse221521 • Sample: DR group R_JS020 • Status: Diabetic retinopathy
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Quality Control Metrics

11,252,575 Total counts Group median: 12,498,211 • 13.7%ile (↓ Low)
27,829 Detected genes Group median: 27,368 • 84.7%ile (↑ High)
7 Mitochondrial fraction (%) Group median: 6 • 70.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

60.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 64.5%
FOXO3 Insulin/IGF-1 Signaling 13.49
bar=donor   line=cohort median 		12.92 54.2%
CETP Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.40 27.2%
SIRT6 Sirtuin Family 4.56
bar=donor   line=cohort median 		3.67 83.7%
SIRT1 Sirtuin Family 3.33
bar=donor   line=cohort median 		3.48 39.6%
SIRT3 Sirtuin Family 1.22
bar=donor   line=cohort median 		1.10 64.0%
IGF1R Insulin/IGF-1 Signaling 2.72
bar=donor   line=cohort median 		4.33 30.8%
KLOTHO Anti-aging 0.12
bar=donor   line=cohort median 		0.06 80.6%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 51.0%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 59.8%
IRS2 Insulin/IGF-1 Signaling 23.58
bar=donor   line=cohort median 		35.28 23.1%
TP53 Tumor Suppression 6.65
bar=donor   line=cohort median 		3.83 97.7%
SHC1 Signal Transduction 11.53
bar=donor   line=cohort median 		8.77 99.2%
ACE Signal Transduction 0.59
bar=donor   line=cohort median 		0.39 80.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,673.7 187,247
2 MT-CO1 ENSG00000198804 protein_coding 7,940.8 137,784
3 S100A9 ENSG00000163220 protein_coding 6,225.1 40,138
4 MT-CO2 ENSG00000198712 protein_coding 5,775.7 44,454
5 MT-ATP6 ENSG00000198899 protein_coding 5,443.0 41,710
6 MT-ND3 ENSG00000198840 protein_coding 5,024.4 19,562
7 MT-ND1 ENSG00000198888 protein_coding 4,917.1 52,895
8 MT-RNR1 ENSG00000211459 Mt_rRNA 4,913.6 52,747
9 MT-CO3 ENSG00000198938 protein_coding 4,657.0 41,084
10 FTL ENSG00000087086 protein_coding 4,347.6 42,611

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,107.3
bar=donor   line=cohort median 		1,223.7 1,385.4 31.3%
2 S100A9 protein_coding 6,225.1
bar=donor   line=cohort median 		7,732.1 9,235.1 24.1%
3 IL1B protein_coding 2.4
bar=donor   line=cohort median 		4.9 6.1 12.2%
4 CXCL8 protein_coding 127.1
bar=donor   line=cohort median 		197.4 207.4 27.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.9
bar=donor   line=cohort median 		2.9 2.4 75.4%
6 FCGR3B protein_coding 45.8
bar=donor   line=cohort median 		108.9 129.3 10.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 470.0
bar=donor   line=cohort median 		581.4 706.2 23.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 77.0
bar=donor   line=cohort median 		51.6 56.4 72.8%
9 CD3E protein_coding 42.3
bar=donor   line=cohort median 		38.1 37.7 61.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.4
bar=donor   line=cohort median 		3.0 3.1 56.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 530.4
bar=donor   line=cohort median 		252.2 281.6 90.9%
12 GNLY protein_coding 68.6
bar=donor   line=cohort median 		58.9 70.7 44.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 725.0
bar=donor   line=cohort median 		585.0 582.1 58.8%
14 HBA1 protein_coding 2,324.2
bar=donor   line=cohort median 		1,960.4 1,960.7 58.3%
15 HBA2 protein_coding 1,642.4
bar=donor   line=cohort median 		1,080.5 1,083.5 65.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,940.8
bar=donor   line=cohort median 		6,740.9 6,938.4 66.6%
17 MT-CO2 protein_coding 5,775.7
bar=donor   line=cohort median 		5,693.7 5,810.8 49.5%
18 MT-ND1 protein_coding 4,917.1
bar=donor   line=cohort median 		3,876.8 3,718.2 78.5%
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