GSM6881415

Dataset: gse221521 • Sample: DR group R_JS021 • Status: Diabetic retinopathy
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Quality Control Metrics

12,710,266 Total counts Group median: 12,498,211 • 53.1%ile (≈ Median)
26,226 Detected genes Group median: 27,368 • 41.2%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 40.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

61.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.19
bar=donor   line=cohort median 		0.17 57.3%
FOXO3 Insulin/IGF-1 Signaling 17.27
bar=donor   line=cohort median 		12.92 80.1%
CETP Lipid Metabolism 0.33
bar=donor   line=cohort median 		0.40 35.0%
SIRT6 Sirtuin Family 4.11
bar=donor   line=cohort median 		3.67 72.3%
SIRT1 Sirtuin Family 3.65
bar=donor   line=cohort median 		3.48 61.4%
SIRT3 Sirtuin Family 0.79
bar=donor   line=cohort median 		1.10 9.1%
IGF1R Insulin/IGF-1 Signaling 5.48
bar=donor   line=cohort median 		4.33 69.2%
KLOTHO Anti-aging 0.21
bar=donor   line=cohort median 		0.06 97.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.11
bar=donor   line=cohort median 		0.07 74.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 56.2%
IRS2 Insulin/IGF-1 Signaling 59.46
bar=donor   line=cohort median 		35.28 80.6%
TP53 Tumor Suppression 4.49
bar=donor   line=cohort median 		3.83 67.1%
SHC1 Signal Transduction 9.79
bar=donor   line=cohort median 		8.77 83.2%
ACE Signal Transduction 0.26
bar=donor   line=cohort median 		0.39 28.8%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 S100A9 ENSG00000163220 protein_coding 12,195.8 88,822
2 MT-RNR2 ENSG00000210082 Mt_rRNA 9,786.9 193,931
3 MT-CO2 ENSG00000198712 protein_coding 5,351.8 46,528
4 MT-CO1 ENSG00000198804 protein_coding 5,297.1 103,820
5 MT-ATP6 ENSG00000198899 protein_coding 4,800.5 41,552
6 DUSP1 ENSG00000120129 protein_coding 4,666.9 119,407
7 FTL ENSG00000087086 protein_coding 4,649.1 51,469
8 MT-RNR1 ENSG00000211459 Mt_rRNA 4,189.9 50,805
9 MT-ND1 ENSG00000198888 protein_coding 4,170.8 50,679
10 MT-TC ENSG00000210140 Mt_tRNA 3,603.6 3,023

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,098.7
bar=donor   line=cohort median 		1,223.7 1,385.4 80.1%
2 S100A9 protein_coding 12,195.8
bar=donor   line=cohort median 		7,732.1 9,235.1 70.7%
3 IL1B protein_coding 7.3
bar=donor   line=cohort median 		4.9 6.1 61.4%
4 CXCL8 protein_coding 150.9
bar=donor   line=cohort median 		197.4 207.4 32.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		2.9 2.4 54.1%
6 FCGR3B protein_coding 65.0
bar=donor   line=cohort median 		108.9 129.3 14.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 857.8
bar=donor   line=cohort median 		581.4 706.2 63.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 33.5
bar=donor   line=cohort median 		51.6 56.4 12.2%
9 CD3E protein_coding 20.4
bar=donor   line=cohort median 		38.1 37.7 7.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.6
bar=donor   line=cohort median 		3.0 3.1 35.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 124.5
bar=donor   line=cohort median 		252.2 281.6 7.5%
12 GNLY protein_coding 18.7
bar=donor   line=cohort median 		58.9 70.7 1.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 392.7
bar=donor   line=cohort median 		585.0 582.1 32.9%
14 HBA1 protein_coding 968.6
bar=donor   line=cohort median 		1,960.4 1,960.7 25.6%
15 HBA2 protein_coding 540.6
bar=donor   line=cohort median 		1,080.5 1,083.5 25.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,297.1
bar=donor   line=cohort median 		6,740.9 6,938.4 17.4%
17 MT-CO2 protein_coding 5,351.8
bar=donor   line=cohort median 		5,693.7 5,810.8 37.0%
18 MT-ND1 protein_coding 4,170.8
bar=donor   line=cohort median 		3,876.8 3,718.2 63.5%
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