GSM6881417

Dataset: gse221521 • Sample: DR group R_JS023 • Status: Diabetic retinopathy
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Quality Control Metrics

12,311,412 Total counts Group median: 12,498,211 • 37.0%ile (≈ Median)
27,042 Detected genes Group median: 27,368 • 68.1%ile (≈ Median)
8 Mitochondrial fraction (%) Group median: 6 • 84.2%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.17 4.9%
FOXO3 Insulin/IGF-1 Signaling 10.97
bar=donor   line=cohort median 		12.92 29.8%
CETP Lipid Metabolism 0.33
bar=donor   line=cohort median 		0.40 33.9%
SIRT6 Sirtuin Family 3.61
bar=donor   line=cohort median 		3.67 45.3%
SIRT1 Sirtuin Family 3.57
bar=donor   line=cohort median 		3.48 57.3%
SIRT3 Sirtuin Family 1.17
bar=donor   line=cohort median 		1.10 60.4%
IGF1R Insulin/IGF-1 Signaling 4.54
bar=donor   line=cohort median 		4.33 52.6%
KLOTHO Anti-aging 0.00
bar=donor   line=cohort median 		0.06 5.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 68.1%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 28.30
bar=donor   line=cohort median 		35.28 37.6%
TP53 Tumor Suppression 7.51
bar=donor   line=cohort median 		3.83 99.7%
SHC1 Signal Transduction 11.10
bar=donor   line=cohort median 		8.77 96.1%
ACE Signal Transduction 0.56
bar=donor   line=cohort median 		0.39 77.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 12,229.7 234,731
2 MT-CO1 ENSG00000198804 protein_coding 9,788.3 185,823
3 MT-CO2 ENSG00000198712 protein_coding 8,065.7 67,921
4 MT-ATP6 ENSG00000198899 protein_coding 6,788.5 56,915
5 MT-ND1 ENSG00000198888 protein_coding 5,001.3 58,864
6 FTL ENSG00000087086 protein_coding 4,962.9 53,218
7 MT-ND4 ENSG00000198886 protein_coding 4,915.0 83,383
8 MT-ATP8 ENSG00000228253 protein_coding 4,693.0 11,960
9 MT-CO3 ENSG00000198938 protein_coding 4,671.1 45,086
10 MT-ND3 ENSG00000198840 protein_coding 4,665.8 19,875

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,076.5
bar=donor   line=cohort median 		1,223.7 1,385.4 28.2%
2 S100A9 protein_coding 4,631.3
bar=donor   line=cohort median 		7,732.1 9,235.1 13.2%
3 IL1B protein_coding 6.2
bar=donor   line=cohort median 		4.9 6.1 51.6%
4 CXCL8 protein_coding 247.7
bar=donor   line=cohort median 		197.4 207.4 57.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.2
bar=donor   line=cohort median 		2.9 2.4 69.2%
6 FCGR3B protein_coding 58.0
bar=donor   line=cohort median 		108.9 129.3 13.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 478.3
bar=donor   line=cohort median 		581.4 706.2 25.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 56.0
bar=donor   line=cohort median 		51.6 56.4 48.4%
9 CD3E protein_coding 45.4
bar=donor   line=cohort median 		38.1 37.7 69.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.4
bar=donor   line=cohort median 		3.0 3.1 76.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 296.3
bar=donor   line=cohort median 		252.2 281.6 54.1%
12 GNLY protein_coding 96.7
bar=donor   line=cohort median 		58.9 70.7 67.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 272.1
bar=donor   line=cohort median 		585.0 582.1 23.6%
14 HBA1 protein_coding 1,404.1
bar=donor   line=cohort median 		1,960.4 1,960.7 37.0%
15 HBA2 protein_coding 507.7
bar=donor   line=cohort median 		1,080.5 1,083.5 23.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,788.3
bar=donor   line=cohort median 		6,740.9 6,938.4 91.5%
17 MT-CO2 protein_coding 8,065.7
bar=donor   line=cohort median 		5,693.7 5,810.8 79.5%
18 MT-ND1 protein_coding 5,001.3
bar=donor   line=cohort median 		3,876.8 3,718.2 79.0%
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