GSM6881419

Dataset: gse221521 • Sample: DR group R_JS024 • Status: Diabetic retinopathy
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Quality Control Metrics

11,167,702 Total counts Group median: 12,498,211 • 12.2%ile (↓ Low)
26,019 Detected genes Group median: 27,368 • 33.9%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 46.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.02
bar=donor   line=cohort median 		0.17 12.2%
FOXO3 Insulin/IGF-1 Signaling 13.27
bar=donor   line=cohort median 		12.92 52.6%
CETP Lipid Metabolism 0.68
bar=donor   line=cohort median 		0.40 87.8%
SIRT6 Sirtuin Family 4.31
bar=donor   line=cohort median 		3.67 79.0%
SIRT1 Sirtuin Family 2.44
bar=donor   line=cohort median 		3.48 6.5%
SIRT3 Sirtuin Family 0.99
bar=donor   line=cohort median 		1.10 30.3%
IGF1R Insulin/IGF-1 Signaling 1.96
bar=donor   line=cohort median 		4.33 17.9%
KLOTHO Anti-aging 0.05
bar=donor   line=cohort median 		0.06 40.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 60.4%
IRS2 Insulin/IGF-1 Signaling 59.96
bar=donor   line=cohort median 		35.28 81.6%
TP53 Tumor Suppression 5.89
bar=donor   line=cohort median 		3.83 91.5%
SHC1 Signal Transduction 11.15
bar=donor   line=cohort median 		8.77 97.7%
ACE Signal Transduction 0.43
bar=donor   line=cohort median 		0.39 57.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 10,199.6 177,579
2 S100A9 ENSG00000163220 protein_coding 7,191.5 46,019
3 MT-CO1 ENSG00000198804 protein_coding 6,587.1 113,434
4 MT-CO2 ENSG00000198712 protein_coding 5,671.4 43,322
5 FTL ENSG00000087086 protein_coding 5,216.8 50,744
6 MT-ATP6 ENSG00000198899 protein_coding 4,877.6 37,095
7 MT-CO3 ENSG00000198938 protein_coding 4,174.6 36,551
8 MT-ATP8 ENSG00000228253 protein_coding 4,053.3 9,370
9 DUSP1 ENSG00000120129 protein_coding 3,812.8 85,714
10 MT-ND1 ENSG00000198888 protein_coding 3,663.3 39,111

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 929.7
bar=donor   line=cohort median 		1,223.7 1,385.4 20.5%
2 S100A9 protein_coding 7,191.5
bar=donor   line=cohort median 		7,732.1 9,235.1 32.9%
3 IL1B protein_coding 4.8
bar=donor   line=cohort median 		4.9 6.1 39.6%
4 CXCL8 protein_coding 296.2
bar=donor   line=cohort median 		197.4 207.4 65.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 6.8
bar=donor   line=cohort median 		2.9 2.4 86.8%
6 FCGR3B protein_coding 92.0
bar=donor   line=cohort median 		108.9 129.3 30.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 472.5
bar=donor   line=cohort median 		581.4 706.2 24.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.0
bar=donor   line=cohort median 		51.6 56.4 38.1%
9 CD3E protein_coding 32.5
bar=donor   line=cohort median 		38.1 37.7 32.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 1.2
bar=donor   line=cohort median 		3.0 3.1 5.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 252.2
bar=donor   line=cohort median 		252.2 281.6 41.7%
12 GNLY protein_coding 66.8
bar=donor   line=cohort median 		58.9 70.7 41.7%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 767.1
bar=donor   line=cohort median 		585.0 582.1 61.9%
14 HBA1 protein_coding 3,058.4
bar=donor   line=cohort median 		1,960.4 1,960.7 65.0%
15 HBA2 protein_coding 1,107.1
bar=donor   line=cohort median 		1,080.5 1,083.5 51.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,587.1
bar=donor   line=cohort median 		6,740.9 6,938.4 41.7%
17 MT-CO2 protein_coding 5,671.4
bar=donor   line=cohort median 		5,693.7 5,810.8 45.9%
18 MT-ND1 protein_coding 3,663.3
bar=donor   line=cohort median 		3,876.8 3,718.2 47.9%
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