GSM6881420

Dataset: gse221521 • Sample: DR group R_JS025 • Status: Diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

12,061,228 Total counts Group median: 12,498,211 • 29.3%ile (≈ Median)
26,474 Detected genes Group median: 27,368 • 50.0%ile (≈ Median)
8 Mitochondrial fraction (%) Group median: 6 • 81.1%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

50.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.37
bar=donor   line=cohort median 		0.17 92.0%
FOXO3 Insulin/IGF-1 Signaling 9.57
bar=donor   line=cohort median 		12.92 18.4%
CETP Lipid Metabolism 0.57
bar=donor   line=cohort median 		0.40 79.5%
SIRT6 Sirtuin Family 5.64
bar=donor   line=cohort median 		3.67 97.7%
SIRT1 Sirtuin Family 2.70
bar=donor   line=cohort median 		3.48 15.8%
SIRT3 Sirtuin Family 1.11
bar=donor   line=cohort median 		1.10 52.6%
IGF1R Insulin/IGF-1 Signaling 2.69
bar=donor   line=cohort median 		4.33 30.3%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 22.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.03
bar=donor   line=cohort median 		0.07 32.9%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 25.11
bar=donor   line=cohort median 		35.28 27.7%
TP53 Tumor Suppression 6.35
bar=donor   line=cohort median 		3.83 95.1%
SHC1 Signal Transduction 10.90
bar=donor   line=cohort median 		8.77 95.6%
ACE Signal Transduction 0.25
bar=donor   line=cohort median 		0.39 24.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 16,803.5 315,964
2 MT-CO2 ENSG00000198712 protein_coding 8,092.0 66,758
3 MT-CO1 ENSG00000198804 protein_coding 6,614.6 123,021
4 S100A9 ENSG00000163220 protein_coding 6,252.4 43,211
5 FTL ENSG00000087086 protein_coding 6,081.5 63,888
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,725.2 65,877
7 MT-ND1 ENSG00000198888 protein_coding 5,444.4 62,777
8 MT-CO3 ENSG00000198938 protein_coding 5,179.2 48,975
9 MT-ATP8 ENSG00000228253 protein_coding 4,429.1 11,058
10 MT-ND4 ENSG00000198886 protein_coding 4,187.6 69,600

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,226.3
bar=donor   line=cohort median 		1,223.7 1,385.4 39.6%
2 S100A9 protein_coding 6,252.4
bar=donor   line=cohort median 		7,732.1 9,235.1 25.1%
3 IL1B protein_coding 4.9
bar=donor   line=cohort median 		4.9 6.1 40.7%
4 CXCL8 protein_coding 335.8
bar=donor   line=cohort median 		197.4 207.4 73.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		2.9 2.4 53.6%
6 FCGR3B protein_coding 124.9
bar=donor   line=cohort median 		108.9 129.3 45.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 191.8
bar=donor   line=cohort median 		581.4 706.2 3.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 64.1
bar=donor   line=cohort median 		51.6 56.4 60.9%
9 CD3E protein_coding 41.6
bar=donor   line=cohort median 		38.1 37.7 61.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.6
bar=donor   line=cohort median 		3.0 3.1 63.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 419.2
bar=donor   line=cohort median 		252.2 281.6 80.1%
12 GNLY protein_coding 73.7
bar=donor   line=cohort median 		58.9 70.7 52.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 629.9
bar=donor   line=cohort median 		585.0 582.1 54.1%
14 HBA1 protein_coding 2,686.3
bar=donor   line=cohort median 		1,960.4 1,960.7 63.0%
15 HBA2 protein_coding 1,080.5
bar=donor   line=cohort median 		1,080.5 1,083.5 49.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,614.6
bar=donor   line=cohort median 		6,740.9 6,938.4 42.2%
17 MT-CO2 protein_coding 8,092.0
bar=donor   line=cohort median 		5,693.7 5,810.8 80.1%
18 MT-ND1 protein_coding 5,444.4
bar=donor   line=cohort median 		3,876.8 3,718.2 83.7%
◂ Previous Donor Back to Donor List Next Donor ▸