GSM6881421

Dataset: gse221521 • Sample: DR group R_JS026 • Status: Diabetic retinopathy
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Quality Control Metrics

12,598,179 Total counts Group median: 12,498,211 • 51.0%ile (≈ Median)
26,795 Detected genes Group median: 27,368 • 61.4%ile (≈ Median)
5 Mitochondrial fraction (%) Group median: 6 • 30.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

60.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.17
bar=donor   line=cohort median 		0.17 51.0%
FOXO3 Insulin/IGF-1 Signaling 10.40
bar=donor   line=cohort median 		12.92 23.6%
CETP Lipid Metabolism 0.56
bar=donor   line=cohort median 		0.40 78.5%
SIRT6 Sirtuin Family 4.80
bar=donor   line=cohort median 		3.67 88.3%
SIRT1 Sirtuin Family 2.43
bar=donor   line=cohort median 		3.48 6.0%
SIRT3 Sirtuin Family 0.99
bar=donor   line=cohort median 		1.10 31.4%
IGF1R Insulin/IGF-1 Signaling 7.08
bar=donor   line=cohort median 		4.33 88.9%
KLOTHO Anti-aging 0.07
bar=donor   line=cohort median 		0.06 55.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 38.6%
TERT Telomere Maintenance 0.09
bar=donor   line=cohort median 		0.01 98.7%
IRS2 Insulin/IGF-1 Signaling 16.22
bar=donor   line=cohort median 		35.28 11.1%
TP53 Tumor Suppression 6.68
bar=donor   line=cohort median 		3.83 98.2%
SHC1 Signal Transduction 10.79
bar=donor   line=cohort median 		8.77 94.0%
ACE Signal Transduction 0.81
bar=donor   line=cohort median 		0.39 92.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 8,881.5 174,438
2 S100A9 ENSG00000163220 protein_coding 6,827.4 49,285
3 MT-CO2 ENSG00000198712 protein_coding 5,091.7 43,876
4 MT-CO1 ENSG00000198804 protein_coding 4,977.0 96,686
5 FTL ENSG00000087086 protein_coding 4,620.2 50,698
6 MT-ND1 ENSG00000198888 protein_coding 4,114.6 49,556
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,049.7 48,672
8 MT-ATP6 ENSG00000198899 protein_coding 3,944.5 33,841
9 MT-ATP8 ENSG00000228253 protein_coding 3,414.0 8,903
10 MT-CO3 ENSG00000198938 protein_coding 3,230.9 31,912

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,099.7
bar=donor   line=cohort median 		1,223.7 1,385.4 30.8%
2 S100A9 protein_coding 6,827.4
bar=donor   line=cohort median 		7,732.1 9,235.1 30.8%
3 IL1B protein_coding 5.9
bar=donor   line=cohort median 		4.9 6.1 49.0%
4 CXCL8 protein_coding 77.9
bar=donor   line=cohort median 		197.4 207.4 13.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.8
bar=donor   line=cohort median 		2.9 2.4 39.6%
6 FCGR3B protein_coding 78.1
bar=donor   line=cohort median 		108.9 129.3 23.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 581.4
bar=donor   line=cohort median 		581.4 706.2 36.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 62.6
bar=donor   line=cohort median 		51.6 56.4 58.8%
9 CD3E protein_coding 40.7
bar=donor   line=cohort median 		38.1 37.7 58.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.6
bar=donor   line=cohort median 		3.0 3.1 36.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 194.5
bar=donor   line=cohort median 		252.2 281.6 24.1%
12 GNLY protein_coding 30.4
bar=donor   line=cohort median 		58.9 70.7 9.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 752.1
bar=donor   line=cohort median 		585.0 582.1 61.4%
14 HBA1 protein_coding 2,403.4
bar=donor   line=cohort median 		1,960.4 1,960.7 60.4%
15 HBA2 protein_coding 921.2
bar=donor   line=cohort median 		1,080.5 1,083.5 43.8%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,977.0
bar=donor   line=cohort median 		6,740.9 6,938.4 13.2%
17 MT-CO2 protein_coding 5,091.7
bar=donor   line=cohort median 		5,693.7 5,810.8 30.3%
18 MT-ND1 protein_coding 4,114.6
bar=donor   line=cohort median 		3,876.8 3,718.2 61.4%
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