GSM6881422

Dataset: gse221521 • Sample: DR group R_JS027 • Status: Diabetic retinopathy
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Quality Control Metrics

16,066,232 Total counts Group median: 12,498,211 • 95.6%ile (↑ High)
25,674 Detected genes Group median: 27,368 • 23.6%ile (↓ Low)
8 Mitochondrial fraction (%) Group median: 6 • 80.1%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

45.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.17 54.7%
FOXO3 Insulin/IGF-1 Signaling 11.35
bar=donor   line=cohort median 		12.92 34.5%
CETP Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.40 7.5%
SIRT6 Sirtuin Family 3.55
bar=donor   line=cohort median 		3.67 43.3%
SIRT1 Sirtuin Family 3.42
bar=donor   line=cohort median 		3.48 43.8%
SIRT3 Sirtuin Family 0.87
bar=donor   line=cohort median 		1.10 14.3%
IGF1R Insulin/IGF-1 Signaling 4.26
bar=donor   line=cohort median 		4.33 49.5%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 68.7%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 71.2%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 35.59
bar=donor   line=cohort median 		35.28 50.5%
TP53 Tumor Suppression 5.92
bar=donor   line=cohort median 		3.83 92.0%
SHC1 Signal Transduction 7.92
bar=donor   line=cohort median 		8.77 18.4%
ACE Signal Transduction 0.44
bar=donor   line=cohort median 		0.39 59.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 13,095.9 328,017
2 MT-CO1 ENSG00000198804 protein_coding 9,191.7 227,717
3 MT-CO2 ENSG00000198712 protein_coding 8,235.2 90,499
4 HBA1 ENSG00000206172 protein_coding 6,693.0 184,955
5 MT-ATP6 ENSG00000198899 protein_coding 6,655.2 72,815
6 S100A9 ENSG00000163220 protein_coding 5,276.7 48,577
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,911.8 75,284
8 MT-ATP8 ENSG00000228253 protein_coding 4,909.3 16,327
9 MT-CO3 ENSG00000198938 protein_coding 4,681.2 58,964
10 FTL ENSG00000087086 protein_coding 4,511.7 63,135

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,111.8
bar=donor   line=cohort median 		1,223.7 1,385.4 32.9%
2 S100A9 protein_coding 5,276.7
bar=donor   line=cohort median 		7,732.1 9,235.1 16.3%
3 IL1B protein_coding 3.7
bar=donor   line=cohort median 		4.9 6.1 24.6%
4 CXCL8 protein_coding 203.9
bar=donor   line=cohort median 		197.4 207.4 49.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 8.7
bar=donor   line=cohort median 		2.9 2.4 92.0%
6 FCGR3B protein_coding 48.5
bar=donor   line=cohort median 		108.9 129.3 10.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 501.1
bar=donor   line=cohort median 		581.4 706.2 27.7%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 39.3
bar=donor   line=cohort median 		51.6 56.4 22.0%
9 CD3E protein_coding 43.0
bar=donor   line=cohort median 		38.1 37.7 64.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.5
bar=donor   line=cohort median 		3.0 3.1 63.0%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 369.2
bar=donor   line=cohort median 		252.2 281.6 71.8%
12 GNLY protein_coding 76.2
bar=donor   line=cohort median 		58.9 70.7 53.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,644.8
bar=donor   line=cohort median 		585.0 582.1 87.3%
14 HBA1 protein_coding 6,693.0
bar=donor   line=cohort median 		1,960.4 1,960.7 86.8%
15 HBA2 protein_coding 2,059.6
bar=donor   line=cohort median 		1,080.5 1,083.5 71.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,191.7
bar=donor   line=cohort median 		6,740.9 6,938.4 86.3%
17 MT-CO2 protein_coding 8,235.2
bar=donor   line=cohort median 		5,693.7 5,810.8 82.1%
18 MT-ND1 protein_coding 4,124.3
bar=donor   line=cohort median 		3,876.8 3,718.2 62.4%
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