GSM6881424

Dataset: gse221521 • Sample: DR group R_JS028 • Status: Diabetic retinopathy
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Quality Control Metrics

13,224,542 Total counts Group median: 12,498,211 • 71.2%ile (≈ Median)
27,558 Detected genes Group median: 27,368 • 78.5%ile (↑ High)
6 Mitochondrial fraction (%) Group median: 6 • 41.7%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

52.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.14
bar=donor   line=cohort median 		0.17 44.3%
FOXO3 Insulin/IGF-1 Signaling 12.68
bar=donor   line=cohort median 		12.92 45.3%
CETP Lipid Metabolism 0.41
bar=donor   line=cohort median 		0.40 53.1%
SIRT6 Sirtuin Family 4.13
bar=donor   line=cohort median 		3.67 72.8%
SIRT1 Sirtuin Family 3.17
bar=donor   line=cohort median 		3.48 35.0%
SIRT3 Sirtuin Family 1.15
bar=donor   line=cohort median 		1.10 58.8%
IGF1R Insulin/IGF-1 Signaling 5.93
bar=donor   line=cohort median 		4.33 76.9%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 79.5%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.06
bar=donor   line=cohort median 		0.07 47.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 33.11
bar=donor   line=cohort median 		35.28 46.4%
TP53 Tumor Suppression 4.88
bar=donor   line=cohort median 		3.83 75.4%
SHC1 Signal Transduction 9.70
bar=donor   line=cohort median 		8.77 81.1%
ACE Signal Transduction 0.15
bar=donor   line=cohort median 		0.39 9.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 12,277.7 253,131
2 S100A9 ENSG00000163220 protein_coding 8,356.9 63,326
3 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,753.6 10,272
4 MT-RNR1 ENSG00000211459 Mt_rRNA 5,280.1 66,615
5 MT-CO1 ENSG00000198804 protein_coding 5,179.9 105,630
6 MT-CO2 ENSG00000198712 protein_coding 4,651.0 42,071
7 FTL ENSG00000087086 protein_coding 4,378.1 50,430
8 MT-CO3 ENSG00000198938 protein_coding 4,258.3 44,150
9 MT-ND3 ENSG00000198840 protein_coding 3,853.6 17,633
10 MT-TC ENSG00000210140 Mt_tRNA 3,127.8 2,730

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,894.9
bar=donor   line=cohort median 		1,223.7 1,385.4 72.3%
2 S100A9 protein_coding 8,356.9
bar=donor   line=cohort median 		7,732.1 9,235.1 43.8%
3 IL1B protein_coding 4.4
bar=donor   line=cohort median 		4.9 6.1 32.4%
4 CXCL8 protein_coding 212.4
bar=donor   line=cohort median 		197.4 207.4 51.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.6
bar=donor   line=cohort median 		2.9 2.4 57.3%
6 FCGR3B protein_coding 100.4
bar=donor   line=cohort median 		108.9 129.3 33.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 577.8
bar=donor   line=cohort median 		581.4 706.2 35.5%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 36.8
bar=donor   line=cohort median 		51.6 56.4 17.4%
9 CD3E protein_coding 19.3
bar=donor   line=cohort median 		38.1 37.7 6.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.1
bar=donor   line=cohort median 		3.0 3.1 21.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 489.9
bar=donor   line=cohort median 		252.2 281.6 87.3%
12 GNLY protein_coding 105.4
bar=donor   line=cohort median 		58.9 70.7 73.3%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,468.3
bar=donor   line=cohort median 		585.0 582.1 84.2%
14 HBA1 protein_coding 3,127.4
bar=donor   line=cohort median 		1,960.4 1,960.7 65.5%
15 HBA2 protein_coding 2,451.1
bar=donor   line=cohort median 		1,080.5 1,083.5 75.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,179.9
bar=donor   line=cohort median 		6,740.9 6,938.4 15.3%
17 MT-CO2 protein_coding 4,651.0
bar=donor   line=cohort median 		5,693.7 5,810.8 19.4%
18 MT-ND1 protein_coding 3,080.9
bar=donor   line=cohort median 		3,876.8 3,718.2 27.7%
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