GSM6881425

Dataset: gse221521 • Sample: DR group R_JS029 • Status: Diabetic retinopathy
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Quality Control Metrics

13,148,731 Total counts Group median: 12,498,211 • 68.7%ile (≈ Median)
27,372 Detected genes Group median: 27,368 • 75.6%ile (↑ High)
8 Mitochondrial fraction (%) Group median: 6 • 82.1%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

67.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.52
bar=donor   line=cohort median 		0.17 97.2%
FOXO3 Insulin/IGF-1 Signaling 9.67
bar=donor   line=cohort median 		12.92 18.9%
CETP Lipid Metabolism 0.54
bar=donor   line=cohort median 		0.40 75.4%
SIRT6 Sirtuin Family 4.72
bar=donor   line=cohort median 		3.67 86.8%
SIRT1 Sirtuin Family 2.74
bar=donor   line=cohort median 		3.48 17.4%
SIRT3 Sirtuin Family 1.12
bar=donor   line=cohort median 		1.10 53.6%
IGF1R Insulin/IGF-1 Signaling 6.54
bar=donor   line=cohort median 		4.33 82.1%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 26.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.17
bar=donor   line=cohort median 		0.07 85.8%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 88.3%
IRS2 Insulin/IGF-1 Signaling 36.53
bar=donor   line=cohort median 		35.28 53.1%
TP53 Tumor Suppression 6.46
bar=donor   line=cohort median 		3.83 96.1%
SHC1 Signal Transduction 10.28
bar=donor   line=cohort median 		8.77 89.9%
ACE Signal Transduction 0.70
bar=donor   line=cohort median 		0.39 87.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 16,344.6 335,046
2 MT-RNR1 ENSG00000211459 Mt_rRNA 8,688.5 108,987
3 S100A9 ENSG00000163220 protein_coding 7,677.5 57,844
4 MT-CO1 ENSG00000198804 protein_coding 6,748.3 136,825
5 MT-CO2 ENSG00000198712 protein_coding 6,582.0 59,197
6 MT-CO3 ENSG00000198938 protein_coding 6,447.3 66,463
7 HBA1 ENSG00000206172 protein_coding 5,198.1 117,560
8 MT-ND1 ENSG00000198888 protein_coding 5,188.2 65,217
9 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,699.5 8,342
10 MT-ND3 ENSG00000198840 protein_coding 4,576.6 20,821

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 864.1
bar=donor   line=cohort median 		1,223.7 1,385.4 16.8%
2 S100A9 protein_coding 7,677.5
bar=donor   line=cohort median 		7,732.1 9,235.1 37.6%
3 IL1B protein_coding 5.5
bar=donor   line=cohort median 		4.9 6.1 45.9%
4 CXCL8 protein_coding 352.9
bar=donor   line=cohort median 		197.4 207.4 75.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.6
bar=donor   line=cohort median 		2.9 2.4 72.8%
6 FCGR3B protein_coding 140.1
bar=donor   line=cohort median 		108.9 129.3 53.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 276.0
bar=donor   line=cohort median 		581.4 706.2 8.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 64.9
bar=donor   line=cohort median 		51.6 56.4 62.4%
9 CD3E protein_coding 39.8
bar=donor   line=cohort median 		38.1 37.7 56.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.9
bar=donor   line=cohort median 		3.0 3.1 42.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 167.1
bar=donor   line=cohort median 		252.2 281.6 17.4%
12 GNLY protein_coding 31.8
bar=donor   line=cohort median 		58.9 70.7 10.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 2,000.6
bar=donor   line=cohort median 		585.0 582.1 92.0%
14 HBA1 protein_coding 5,198.1
bar=donor   line=cohort median 		1,960.4 1,960.7 79.5%
15 HBA2 protein_coding 4,241.2
bar=donor   line=cohort median 		1,080.5 1,083.5 88.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,748.3
bar=donor   line=cohort median 		6,740.9 6,938.4 45.3%
17 MT-CO2 protein_coding 6,582.0
bar=donor   line=cohort median 		5,693.7 5,810.8 65.5%
18 MT-ND1 protein_coding 5,188.2
bar=donor   line=cohort median 		3,876.8 3,718.2 81.1%
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