GSM6881426

Dataset: gse221521 • Sample: DR group R_JS030 • Status: Diabetic retinopathy
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Quality Control Metrics

12,478,318 Total counts Group median: 12,498,211 • 44.8%ile (≈ Median)
26,651 Detected genes Group median: 27,368 • 56.7%ile (≈ Median)
9 Mitochondrial fraction (%) Group median: 6 • 89.9%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

60.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 65.0%
FOXO3 Insulin/IGF-1 Signaling 11.40
bar=donor   line=cohort median 		12.92 35.5%
CETP Lipid Metabolism 0.47
bar=donor   line=cohort median 		0.40 66.6%
SIRT6 Sirtuin Family 3.46
bar=donor   line=cohort median 		3.67 38.6%
SIRT1 Sirtuin Family 4.01
bar=donor   line=cohort median 		3.48 70.7%
SIRT3 Sirtuin Family 1.09
bar=donor   line=cohort median 		1.10 48.5%
IGF1R Insulin/IGF-1 Signaling 10.32
bar=donor   line=cohort median 		4.33 97.7%
KLOTHO Anti-aging 0.15
bar=donor   line=cohort median 		0.06 87.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 80.6%
IRS2 Insulin/IGF-1 Signaling 37.42
bar=donor   line=cohort median 		35.28 54.2%
TP53 Tumor Suppression 5.30
bar=donor   line=cohort median 		3.83 82.1%
SHC1 Signal Transduction 9.17
bar=donor   line=cohort median 		8.77 63.0%
ACE Signal Transduction 0.46
bar=donor   line=cohort median 		0.39 61.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 18,624.0 362,305
2 MT-CO1 ENSG00000198804 protein_coding 7,992.6 153,791
3 MT-ATP6 ENSG00000198899 protein_coding 7,569.8 64,326
4 MT-RNR1 ENSG00000211459 Mt_rRNA 7,358.3 87,596
5 MT-CO2 ENSG00000198712 protein_coding 7,296.8 62,279
6 MT-CO3 ENSG00000198938 protein_coding 5,965.8 58,363
7 S100A9 ENSG00000163220 protein_coding 5,899.9 42,185
8 MT-ND3 ENSG00000198840 protein_coding 5,658.8 24,432
9 MT-ND1 ENSG00000198888 protein_coding 5,602.4 66,833
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,616.6 7,777

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,724.0
bar=donor   line=cohort median 		1,223.7 1,385.4 64.5%
2 S100A9 protein_coding 5,899.9
bar=donor   line=cohort median 		7,732.1 9,235.1 20.5%
3 IL1B protein_coding 8.0
bar=donor   line=cohort median 		4.9 6.1 65.5%
4 CXCL8 protein_coding 99.4
bar=donor   line=cohort median 		197.4 207.4 19.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		2.9 2.4 52.6%
6 FCGR3B protein_coding 121.5
bar=donor   line=cohort median 		108.9 129.3 44.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 347.1
bar=donor   line=cohort median 		581.4 706.2 14.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 41.8
bar=donor   line=cohort median 		51.6 56.4 26.7%
9 CD3E protein_coding 39.1
bar=donor   line=cohort median 		38.1 37.7 54.7%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.8
bar=donor   line=cohort median 		3.0 3.1 80.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 173.2
bar=donor   line=cohort median 		252.2 281.6 19.9%
12 GNLY protein_coding 41.7
bar=donor   line=cohort median 		58.9 70.7 17.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 638.9
bar=donor   line=cohort median 		585.0 582.1 54.7%
14 HBA1 protein_coding 1,050.6
bar=donor   line=cohort median 		1,960.4 1,960.7 28.8%
15 HBA2 protein_coding 745.1
bar=donor   line=cohort median 		1,080.5 1,083.5 35.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 7,992.6
bar=donor   line=cohort median 		6,740.9 6,938.4 67.1%
17 MT-CO2 protein_coding 7,296.8
bar=donor   line=cohort median 		5,693.7 5,810.8 71.8%
18 MT-ND1 protein_coding 5,602.4
bar=donor   line=cohort median 		3,876.8 3,718.2 85.2%
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