GSM6881427

Dataset: gse221521 • Sample: DR group R_JS031 • Status: Diabetic retinopathy
◂ Prev All Donors Next ▸

Quality Control Metrics

11,202,852 Total counts Group median: 12,498,211 • 12.7%ile (↓ Low)
28,013 Detected genes Group median: 27,368 • 89.4%ile (↑ High)
7 Mitochondrial fraction (%) Group median: 6 • 68.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

69.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.19
bar=donor   line=cohort median 		0.17 58.3%
FOXO3 Insulin/IGF-1 Signaling 11.99
bar=donor   line=cohort median 		12.92 40.2%
CETP Lipid Metabolism 0.80
bar=donor   line=cohort median 		0.40 92.0%
SIRT6 Sirtuin Family 3.73
bar=donor   line=cohort median 		3.67 52.6%
SIRT1 Sirtuin Family 3.45
bar=donor   line=cohort median 		3.48 47.4%
SIRT3 Sirtuin Family 1.45
bar=donor   line=cohort median 		1.10 91.5%
IGF1R Insulin/IGF-1 Signaling 5.73
bar=donor   line=cohort median 		4.33 75.4%
KLOTHO Anti-aging 0.09
bar=donor   line=cohort median 		0.06 69.2%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.13
bar=donor   line=cohort median 		0.07 80.6%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 75.9%
IRS2 Insulin/IGF-1 Signaling 41.05
bar=donor   line=cohort median 		35.28 59.3%
TP53 Tumor Suppression 5.49
bar=donor   line=cohort median 		3.83 86.3%
SHC1 Signal Transduction 10.53
bar=donor   line=cohort median 		8.77 93.0%
ACE Signal Transduction 0.48
bar=donor   line=cohort median 		0.39 64.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,500.2 200,854
2 S100A9 ENSG00000163220 protein_coding 8,534.4 54,784
3 MT-CO1 ENSG00000198804 protein_coding 8,089.4 139,742
4 MT-RNR1 ENSG00000211459 Mt_rRNA 6,640.5 70,971
5 MT-CO3 ENSG00000198938 protein_coding 5,523.3 48,511
6 MT-CO2 ENSG00000198712 protein_coding 5,300.6 40,617
7 MT-ND1 ENSG00000198888 protein_coding 4,458.7 47,752
8 TMSB4XP8 ENSG00000187653 processed_pseudogene 4,292.6 6,492
9 FTL ENSG00000087086 protein_coding 4,043.8 39,458
10 MT-ND4 ENSG00000198886 protein_coding 3,826.8 59,077

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,378.2
bar=donor   line=cohort median 		1,223.7 1,385.4 49.0%
2 S100A9 protein_coding 8,534.4
bar=donor   line=cohort median 		7,732.1 9,235.1 45.9%
3 IL1B protein_coding 8.7
bar=donor   line=cohort median 		4.9 6.1 69.2%
4 CXCL8 protein_coding 175.7
bar=donor   line=cohort median 		197.4 207.4 39.6%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 5.0
bar=donor   line=cohort median 		2.9 2.4 81.1%
6 FCGR3B protein_coding 76.4
bar=donor   line=cohort median 		108.9 129.3 20.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 585.9
bar=donor   line=cohort median 		581.4 706.2 37.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 42.6
bar=donor   line=cohort median 		51.6 56.4 28.2%
9 CD3E protein_coding 32.9
bar=donor   line=cohort median 		38.1 37.7 33.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.9
bar=donor   line=cohort median 		3.0 3.1 66.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 225.2
bar=donor   line=cohort median 		252.2 281.6 30.8%
12 GNLY protein_coding 72.6
bar=donor   line=cohort median 		58.9 70.7 51.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,257.9
bar=donor   line=cohort median 		585.0 582.1 80.1%
14 HBA1 protein_coding 3,286.7
bar=donor   line=cohort median 		1,960.4 1,960.7 67.1%
15 HBA2 protein_coding 2,396.2
bar=donor   line=cohort median 		1,080.5 1,083.5 75.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 8,089.4
bar=donor   line=cohort median 		6,740.9 6,938.4 68.1%
17 MT-CO2 protein_coding 5,300.6
bar=donor   line=cohort median 		5,693.7 5,810.8 35.0%
18 MT-ND1 protein_coding 4,458.7
bar=donor   line=cohort median 		3,876.8 3,718.2 71.2%
◂ Previous Donor Back to Donor List Next Donor ▸