GSM6881428

Dataset: gse221521 • Sample: DR group R_JS032 • Status: Diabetic retinopathy
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Quality Control Metrics

14,561,447 Total counts Group median: 12,498,211 • 89.4%ile (↑ High)
25,762 Detected genes Group median: 27,368 • 25.1%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 39.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

34.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.11
bar=donor   line=cohort median 		0.17 34.5%
FOXO3 Insulin/IGF-1 Signaling 8.51
bar=donor   line=cohort median 		12.92 15.3%
CETP Lipid Metabolism 0.31
bar=donor   line=cohort median 		0.40 29.3%
SIRT6 Sirtuin Family 4.58
bar=donor   line=cohort median 		3.67 84.7%
SIRT1 Sirtuin Family 2.45
bar=donor   line=cohort median 		3.48 7.0%
SIRT3 Sirtuin Family 0.72
bar=donor   line=cohort median 		1.10 6.5%
IGF1R Insulin/IGF-1 Signaling 4.96
bar=donor   line=cohort median 		4.33 61.4%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 47.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 19.87
bar=donor   line=cohort median 		35.28 17.9%
TP53 Tumor Suppression 2.99
bar=donor   line=cohort median 		3.83 21.0%
SHC1 Signal Transduction 9.48
bar=donor   line=cohort median 		8.77 74.4%
ACE Signal Transduction 0.29
bar=donor   line=cohort median 		0.39 33.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 12,462.7 282,919
2 S100A9 ENSG00000163220 protein_coding 12,445.2 103,839
3 HBA1 ENSG00000206172 protein_coding 7,003.3 175,403
4 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,714.2 11,233
5 MT-RNR1 ENSG00000211459 Mt_rRNA 5,431.0 75,446
6 MT-CO1 ENSG00000198804 protein_coding 5,327.5 119,623
7 MT-CO2 ENSG00000198712 protein_coding 5,196.7 51,759
8 FTL ENSG00000087086 protein_coding 5,046.6 64,006
9 HBA2 ENSG00000188536 protein_coding 4,619.7 113,551
10 MT-CO3 ENSG00000198938 protein_coding 4,486.7 51,221

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 2,362.7
bar=donor   line=cohort median 		1,223.7 1,385.4 85.2%
2 S100A9 protein_coding 12,445.2
bar=donor   line=cohort median 		7,732.1 9,235.1 72.8%
3 IL1B protein_coding 12.8
bar=donor   line=cohort median 		4.9 6.1 85.8%
4 CXCL8 protein_coding 164.4
bar=donor   line=cohort median 		197.4 207.4 36.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 7.5
bar=donor   line=cohort median 		2.9 2.4 89.4%
6 FCGR3B protein_coding 86.1
bar=donor   line=cohort median 		108.9 129.3 26.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 426.5
bar=donor   line=cohort median 		581.4 706.2 19.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 49.7
bar=donor   line=cohort median 		51.6 56.4 40.2%
9 CD3E protein_coding 22.6
bar=donor   line=cohort median 		38.1 37.7 9.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.0
bar=donor   line=cohort median 		3.0 3.1 48.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 268.0
bar=donor   line=cohort median 		252.2 281.6 45.3%
12 GNLY protein_coding 48.9
bar=donor   line=cohort median 		58.9 70.7 26.2%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 3,252.1
bar=donor   line=cohort median 		585.0 582.1 96.6%
14 HBA1 protein_coding 7,003.3
bar=donor   line=cohort median 		1,960.4 1,960.7 87.8%
15 HBA2 protein_coding 4,619.7
bar=donor   line=cohort median 		1,080.5 1,083.5 91.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,327.5
bar=donor   line=cohort median 		6,740.9 6,938.4 18.4%
17 MT-CO2 protein_coding 5,196.7
bar=donor   line=cohort median 		5,693.7 5,810.8 33.4%
18 MT-ND1 protein_coding 2,745.8
bar=donor   line=cohort median 		3,876.8 3,718.2 19.4%
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