GSM6881429

Dataset: gse221521 • Sample: DR group R_JS033 • Status: Diabetic retinopathy
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Quality Control Metrics

11,722,581 Total counts Group median: 12,498,211 • 21.5%ile (↓ Low)
25,841 Detected genes Group median: 27,368 • 28.8%ile (≈ Median)
9 Mitochondrial fraction (%) Group median: 6 • 92.0%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

66.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.18
bar=donor   line=cohort median 		0.17 54.2%
FOXO3 Insulin/IGF-1 Signaling 7.86
bar=donor   line=cohort median 		12.92 13.2%
CETP Lipid Metabolism 0.44
bar=donor   line=cohort median 		0.40 60.9%
SIRT6 Sirtuin Family 4.49
bar=donor   line=cohort median 		3.67 82.1%
SIRT1 Sirtuin Family 3.48
bar=donor   line=cohort median 		3.48 51.0%
SIRT3 Sirtuin Family 1.45
bar=donor   line=cohort median 		1.10 90.9%
IGF1R Insulin/IGF-1 Signaling 4.83
bar=donor   line=cohort median 		4.33 58.8%
KLOTHO Anti-aging 0.14
bar=donor   line=cohort median 		0.06 85.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 42.2%
TERT Telomere Maintenance 0.04
bar=donor   line=cohort median 		0.01 82.6%
IRS2 Insulin/IGF-1 Signaling 26.49
bar=donor   line=cohort median 		35.28 33.4%
TP53 Tumor Suppression 6.28
bar=donor   line=cohort median 		3.83 94.6%
SHC1 Signal Transduction 10.80
bar=donor   line=cohort median 		8.77 94.6%
ACE Signal Transduction 1.05
bar=donor   line=cohort median 		0.39 97.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 16,107.2 294,367
2 MT-CO1 ENSG00000198804 protein_coding 9,657.8 174,577
3 MT-CO2 ENSG00000198712 protein_coding 9,546.5 76,546
4 MT-ATP6 ENSG00000198899 protein_coding 9,129.4 72,881
5 MT-ND3 ENSG00000198840 protein_coding 7,075.2 28,697
6 TMSB4XP8 ENSG00000187653 processed_pseudogene 6,991.3 11,064
7 MT-RNR1 ENSG00000211459 Mt_rRNA 6,176.7 69,076
8 MT-ND1 ENSG00000198888 protein_coding 6,157.8 69,009
9 MT-CO3 ENSG00000198938 protein_coding 5,606.9 51,530
10 FTL ENSG00000087086 protein_coding 5,290.7 54,020

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,353.9
bar=donor   line=cohort median 		1,223.7 1,385.4 46.9%
2 S100A9 protein_coding 4,736.6
bar=donor   line=cohort median 		7,732.1 9,235.1 14.2%
3 IL1B protein_coding 7.4
bar=donor   line=cohort median 		4.9 6.1 64.0%
4 CXCL8 protein_coding 197.4
bar=donor   line=cohort median 		197.4 207.4 45.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.8
bar=donor   line=cohort median 		2.9 2.4 74.9%
6 FCGR3B protein_coding 145.9
bar=donor   line=cohort median 		108.9 129.3 56.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 516.2
bar=donor   line=cohort median 		581.4 706.2 30.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 60.1
bar=donor   line=cohort median 		51.6 56.4 57.3%
9 CD3E protein_coding 49.7
bar=donor   line=cohort median 		38.1 37.7 75.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.9
bar=donor   line=cohort median 		3.0 3.1 44.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 328.1
bar=donor   line=cohort median 		252.2 281.6 64.0%
12 GNLY protein_coding 68.8
bar=donor   line=cohort median 		58.9 70.7 45.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 726.2
bar=donor   line=cohort median 		585.0 582.1 59.3%
14 HBA1 protein_coding 1,163.3
bar=donor   line=cohort median 		1,960.4 1,960.7 32.4%
15 HBA2 protein_coding 801.0
bar=donor   line=cohort median 		1,080.5 1,083.5 39.1%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 9,657.8
bar=donor   line=cohort median 		6,740.9 6,938.4 89.9%
17 MT-CO2 protein_coding 9,546.5
bar=donor   line=cohort median 		5,693.7 5,810.8 90.4%
18 MT-ND1 protein_coding 6,157.8
bar=donor   line=cohort median 		3,876.8 3,718.2 90.4%
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