GSM6881431

Dataset: gse221521 • Sample: DR group R_JS034 • Status: Diabetic retinopathy
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Quality Control Metrics

12,508,363 Total counts Group median: 12,498,211 • 47.4%ile (≈ Median)
28,290 Detected genes Group median: 27,368 • 90.9%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 35.0%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

67.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.19
bar=donor   line=cohort median 		0.17 58.8%
FOXO3 Insulin/IGF-1 Signaling 15.60
bar=donor   line=cohort median 		12.92 70.2%
CETP Lipid Metabolism 0.40
bar=donor   line=cohort median 		0.40 49.5%
SIRT6 Sirtuin Family 4.05
bar=donor   line=cohort median 		3.67 69.2%
SIRT1 Sirtuin Family 3.46
bar=donor   line=cohort median 		3.48 47.9%
SIRT3 Sirtuin Family 1.33
bar=donor   line=cohort median 		1.10 82.6%
IGF1R Insulin/IGF-1 Signaling 11.68
bar=donor   line=cohort median 		4.33 99.2%
KLOTHO Anti-aging 0.06
bar=donor   line=cohort median 		0.06 45.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.05
bar=donor   line=cohort median 		0.07 40.7%
TERT Telomere Maintenance 0.08
bar=donor   line=cohort median 		0.01 97.7%
IRS2 Insulin/IGF-1 Signaling 50.64
bar=donor   line=cohort median 		35.28 74.4%
TP53 Tumor Suppression 4.82
bar=donor   line=cohort median 		3.83 73.8%
SHC1 Signal Transduction 9.63
bar=donor   line=cohort median 		8.77 79.0%
ACE Signal Transduction 0.49
bar=donor   line=cohort median 		0.39 67.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,417.4 183,645
2 S100A9 ENSG00000163220 protein_coding 6,683.3 47,901
3 MT-CO1 ENSG00000198804 protein_coding 5,240.1 101,071
4 MT-RNR1 ENSG00000211459 Mt_rRNA 5,083.3 60,659
5 HBA1 ENSG00000206172 protein_coding 4,756.9 102,341
6 MT-CO2 ENSG00000198712 protein_coding 4,142.4 35,441
7 FTL ENSG00000087086 protein_coding 4,067.9 44,319
8 MT-ATP6 ENSG00000198899 protein_coding 3,865.1 32,924
9 MT-ND1 ENSG00000198888 protein_coding 3,760.1 44,963
10 MT-CO3 ENSG00000198938 protein_coding 3,266.1 32,029

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,093.5
bar=donor   line=cohort median 		1,223.7 1,385.4 29.8%
2 S100A9 protein_coding 6,683.3
bar=donor   line=cohort median 		7,732.1 9,235.1 30.3%
3 IL1B protein_coding 10.4
bar=donor   line=cohort median 		4.9 6.1 79.5%
4 CXCL8 protein_coding 251.1
bar=donor   line=cohort median 		197.4 207.4 59.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.4
bar=donor   line=cohort median 		2.9 2.4 71.8%
6 FCGR3B protein_coding 68.9
bar=donor   line=cohort median 		108.9 129.3 16.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 288.9
bar=donor   line=cohort median 		581.4 706.2 10.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 38.9
bar=donor   line=cohort median 		51.6 56.4 20.5%
9 CD3E protein_coding 27.0
bar=donor   line=cohort median 		38.1 37.7 18.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.0 3.1 30.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 171.5
bar=donor   line=cohort median 		252.2 281.6 18.4%
12 GNLY protein_coding 32.4
bar=donor   line=cohort median 		58.9 70.7 10.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,231.4
bar=donor   line=cohort median 		585.0 582.1 78.5%
14 HBA1 protein_coding 4,756.9
bar=donor   line=cohort median 		1,960.4 1,960.7 76.9%
15 HBA2 protein_coding 2,297.1
bar=donor   line=cohort median 		1,080.5 1,083.5 74.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,240.1
bar=donor   line=cohort median 		6,740.9 6,938.4 16.3%
17 MT-CO2 protein_coding 4,142.4
bar=donor   line=cohort median 		5,693.7 5,810.8 13.2%
18 MT-ND1 protein_coding 3,760.1
bar=donor   line=cohort median 		3,876.8 3,718.2 52.1%
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