GSM6881432

Dataset: gse221521 • Sample: DR group R_JS035 • Status: Diabetic retinopathy
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Quality Control Metrics

12,869,185 Total counts Group median: 12,498,211 • 59.8%ile (≈ Median)
26,464 Detected genes Group median: 27,368 • 49.5%ile (≈ Median)
11 Mitochondrial fraction (%) Group median: 6 • 95.6%ile (↑ High)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

42.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.29
bar=donor   line=cohort median 		0.17 79.0%
FOXO3 Insulin/IGF-1 Signaling 10.06
bar=donor   line=cohort median 		12.92 21.0%
CETP Lipid Metabolism 0.31
bar=donor   line=cohort median 		0.40 30.8%
SIRT6 Sirtuin Family 2.95
bar=donor   line=cohort median 		3.67 18.4%
SIRT1 Sirtuin Family 4.83
bar=donor   line=cohort median 		3.48 87.3%
SIRT3 Sirtuin Family 0.88
bar=donor   line=cohort median 		1.10 15.3%
IGF1R Insulin/IGF-1 Signaling 0.90
bar=donor   line=cohort median 		4.33 8.6%
KLOTHO Anti-aging 0.11
bar=donor   line=cohort median 		0.06 73.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.02
bar=donor   line=cohort median 		0.07 23.1%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 37.58
bar=donor   line=cohort median 		35.28 55.2%
TP53 Tumor Suppression 5.57
bar=donor   line=cohort median 		3.83 86.8%
SHC1 Signal Transduction 8.26
bar=donor   line=cohort median 		8.77 32.4%
ACE Signal Transduction 0.31
bar=donor   line=cohort median 		0.39 37.6%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 22,500.1 451,420
2 MT-CO1 ENSG00000198804 protein_coding 10,795.9 214,236
3 MT-CO2 ENSG00000198712 protein_coding 9,351.2 82,314
4 MT-ATP6 ENSG00000198899 protein_coding 8,971.3 78,624
5 MT-CO3 ENSG00000198938 protein_coding 7,020.4 70,832
6 MT-RNR1 ENSG00000211459 Mt_rRNA 6,719.4 82,496
7 MT-ATP8 ENSG00000228253 protein_coding 5,801.6 15,455
8 MT-ND4 ENSG00000198886 protein_coding 5,776.0 102,430
9 MT-ND1 ENSG00000198888 protein_coding 5,637.3 69,355
10 TMSB4XP8 ENSG00000187653 processed_pseudogene 5,125.7 8,905

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 864.9
bar=donor   line=cohort median 		1,223.7 1,385.4 17.4%
2 S100A9 protein_coding 3,327.2
bar=donor   line=cohort median 		7,732.1 9,235.1 9.1%
3 IL1B protein_coding 4.5
bar=donor   line=cohort median 		4.9 6.1 35.5%
4 CXCL8 protein_coding 139.5
bar=donor   line=cohort median 		197.4 207.4 29.8%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.1
bar=donor   line=cohort median 		2.9 2.4 66.1%
6 FCGR3B protein_coding 77.4
bar=donor   line=cohort median 		108.9 129.3 21.0%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 522.1
bar=donor   line=cohort median 		581.4 706.2 31.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 56.4
bar=donor   line=cohort median 		51.6 56.4 50.0%
9 CD3E protein_coding 52.5
bar=donor   line=cohort median 		38.1 37.7 80.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 3.8
bar=donor   line=cohort median 		3.0 3.1 65.5%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 292.3
bar=donor   line=cohort median 		252.2 281.6 53.1%
12 GNLY protein_coding 114.3
bar=donor   line=cohort median 		58.9 70.7 78.0%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,181.5
bar=donor   line=cohort median 		585.0 582.1 76.9%
14 HBA1 protein_coding 3,672.5
bar=donor   line=cohort median 		1,960.4 1,960.7 70.2%
15 HBA2 protein_coding 1,315.6
bar=donor   line=cohort median 		1,080.5 1,083.5 61.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 10,795.9
bar=donor   line=cohort median 		6,740.9 6,938.4 94.6%
17 MT-CO2 protein_coding 9,351.2
bar=donor   line=cohort median 		5,693.7 5,810.8 88.9%
18 MT-ND1 protein_coding 5,637.3
bar=donor   line=cohort median 		3,876.8 3,718.2 86.3%
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