GSM6881433

Dataset: gse221521 • Sample: DR group R_JS036 • Status: Diabetic retinopathy
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Quality Control Metrics

14,004,407 Total counts Group median: 12,498,211 • 83.7%ile (↑ High)
28,455 Detected genes Group median: 27,368 • 93.0%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 32.9%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

61.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.30
bar=donor   line=cohort median 		0.17 82.1%
FOXO3 Insulin/IGF-1 Signaling 12.22
bar=donor   line=cohort median 		12.92 41.7%
CETP Lipid Metabolism 0.67
bar=donor   line=cohort median 		0.40 86.8%
SIRT6 Sirtuin Family 3.95
bar=donor   line=cohort median 		3.67 63.5%
SIRT1 Sirtuin Family 2.57
bar=donor   line=cohort median 		3.48 11.1%
SIRT3 Sirtuin Family 1.29
bar=donor   line=cohort median 		1.10 77.5%
IGF1R Insulin/IGF-1 Signaling 2.99
bar=donor   line=cohort median 		4.33 33.4%
KLOTHO Anti-aging 0.03
bar=donor   line=cohort median 		0.06 24.1%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.07
bar=donor   line=cohort median 		0.07 51.6%
TERT Telomere Maintenance 0.05
bar=donor   line=cohort median 		0.01 87.3%
IRS2 Insulin/IGF-1 Signaling 34.20
bar=donor   line=cohort median 		35.28 49.5%
TP53 Tumor Suppression 6.06
bar=donor   line=cohort median 		3.83 93.0%
SHC1 Signal Transduction 10.36
bar=donor   line=cohort median 		8.77 90.4%
ACE Signal Transduction 0.58
bar=donor   line=cohort median 		0.39 78.5%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 9,103.7 198,760
2 MT-CO1 ENSG00000198804 protein_coding 5,507.7 118,938
3 MT-CO2 ENSG00000198712 protein_coding 5,014.0 48,029
4 MT-RNR1 ENSG00000211459 Mt_rRNA 4,911.8 65,622
5 FTL ENSG00000087086 protein_coding 4,151.0 50,633
6 S100A9 ENSG00000163220 protein_coding 4,132.6 33,162
7 MT-CO3 ENSG00000198938 protein_coding 3,771.2 41,406
8 MT-ND1 ENSG00000198888 protein_coding 3,622.7 48,502
9 HBA1 ENSG00000206172 protein_coding 3,209.2 77,302
10 MT-TC ENSG00000210140 Mt_tRNA 2,976.3 2,751

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 627.7
bar=donor   line=cohort median 		1,223.7 1,385.4 10.1%
2 S100A9 protein_coding 4,132.6
bar=donor   line=cohort median 		7,732.1 9,235.1 12.2%
3 IL1B protein_coding 3.8
bar=donor   line=cohort median 		4.9 6.1 25.1%
4 CXCL8 protein_coding 72.3
bar=donor   line=cohort median 		197.4 207.4 12.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 1.7
bar=donor   line=cohort median 		2.9 2.4 36.0%
6 FCGR3B protein_coding 50.4
bar=donor   line=cohort median 		108.9 129.3 11.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 449.7
bar=donor   line=cohort median 		581.4 706.2 22.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 56.0
bar=donor   line=cohort median 		51.6 56.4 49.0%
9 CD3E protein_coding 37.7
bar=donor   line=cohort median 		38.1 37.7 50.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.7
bar=donor   line=cohort median 		3.0 3.1 39.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 256.1
bar=donor   line=cohort median 		252.2 281.6 42.2%
12 GNLY protein_coding 56.3
bar=donor   line=cohort median 		58.9 70.7 33.4%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 824.5
bar=donor   line=cohort median 		585.0 582.1 65.0%
14 HBA1 protein_coding 3,209.2
bar=donor   line=cohort median 		1,960.4 1,960.7 66.6%
15 HBA2 protein_coding 1,173.5
bar=donor   line=cohort median 		1,080.5 1,083.5 54.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,507.7
bar=donor   line=cohort median 		6,740.9 6,938.4 22.0%
17 MT-CO2 protein_coding 5,014.0
bar=donor   line=cohort median 		5,693.7 5,810.8 28.2%
18 MT-ND1 protein_coding 3,622.7
bar=donor   line=cohort median 		3,876.8 3,718.2 46.4%
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