GSM6881434

Dataset: gse221521 • Sample: DR group R_JS037 • Status: Diabetic retinopathy
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Quality Control Metrics

11,040,710 Total counts Group median: 12,498,211 • 10.1%ile (↓ Low)
25,291 Detected genes Group median: 27,368 • 16.3%ile (↓ Low)
7 Mitochondrial fraction (%) Group median: 6 • 72.8%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

43.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.05
bar=donor   line=cohort median 		0.17 16.8%
FOXO3 Insulin/IGF-1 Signaling 9.72
bar=donor   line=cohort median 		12.92 19.4%
CETP Lipid Metabolism 0.38
bar=donor   line=cohort median 		0.40 46.4%
SIRT6 Sirtuin Family 3.37
bar=donor   line=cohort median 		3.67 31.9%
SIRT1 Sirtuin Family 4.10
bar=donor   line=cohort median 		3.48 73.8%
SIRT3 Sirtuin Family 0.98
bar=donor   line=cohort median 		1.10 28.8%
IGF1R Insulin/IGF-1 Signaling 1.02
bar=donor   line=cohort median 		4.33 10.6%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 33.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.00
bar=donor   line=cohort median 		0.07 10.4%
TERT Telomere Maintenance 0.02
bar=donor   line=cohort median 		0.01 60.9%
IRS2 Insulin/IGF-1 Signaling 23.73
bar=donor   line=cohort median 		35.28 23.6%
TP53 Tumor Suppression 6.98
bar=donor   line=cohort median 		3.83 99.2%
SHC1 Signal Transduction 9.43
bar=donor   line=cohort median 		8.77 71.8%
ACE Signal Transduction 0.51
bar=donor   line=cohort median 		0.39 71.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 13,678.4 235,439
2 MT-CO2 ENSG00000198712 protein_coding 7,538.7 56,931
3 MT-CO1 ENSG00000198804 protein_coding 6,722.4 114,447
4 MT-ATP6 ENSG00000198899 protein_coding 6,479.3 48,716
5 HBA1 ENSG00000206172 protein_coding 5,832.5 110,760
6 MT-ATP8 ENSG00000228253 protein_coding 4,889.2 11,174
7 S100A9 ENSG00000163220 protein_coding 4,851.0 30,689
8 RPS28P7 ENSG00000227097 processed_pseudogene 4,589.5 10,641
9 FTL ENSG00000087086 protein_coding 4,389.7 42,213
10 MT-RNR1 ENSG00000211459 Mt_rRNA 4,237.3 44,631

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,074.7
bar=donor   line=cohort median 		1,223.7 1,385.4 27.7%
2 S100A9 protein_coding 4,851.0
bar=donor   line=cohort median 		7,732.1 9,235.1 14.8%
3 IL1B protein_coding 2.2
bar=donor   line=cohort median 		4.9 6.1 10.6%
4 CXCL8 protein_coding 35.5
bar=donor   line=cohort median 		197.4 207.4 6.5%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 3.1
bar=donor   line=cohort median 		2.9 2.4 66.6%
6 FCGR3B protein_coding 84.7
bar=donor   line=cohort median 		108.9 129.3 25.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 605.4
bar=donor   line=cohort median 		581.4 706.2 39.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 84.9
bar=donor   line=cohort median 		51.6 56.4 81.6%
9 CD3E protein_coding 47.1
bar=donor   line=cohort median 		38.1 37.7 72.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 4.0
bar=donor   line=cohort median 		3.0 3.1 71.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 225.4
bar=donor   line=cohort median 		252.2 281.6 31.3%
12 GNLY protein_coding 47.9
bar=donor   line=cohort median 		58.9 70.7 24.6%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,303.6
bar=donor   line=cohort median 		585.0 582.1 80.6%
14 HBA1 protein_coding 5,832.5
bar=donor   line=cohort median 		1,960.4 1,960.7 83.2%
15 HBA2 protein_coding 1,283.3
bar=donor   line=cohort median 		1,080.5 1,083.5 60.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,722.4
bar=donor   line=cohort median 		6,740.9 6,938.4 44.3%
17 MT-CO2 protein_coding 7,538.7
bar=donor   line=cohort median 		5,693.7 5,810.8 74.9%
18 MT-ND1 protein_coding 3,511.8
bar=donor   line=cohort median 		3,876.8 3,718.2 41.2%
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