GSM6881435

Dataset: gse221521 • Sample: DR group R_JS038 • Status: Diabetic retinopathy
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Quality Control Metrics

11,659,587 Total counts Group median: 12,498,211 • 18.4%ile (↓ Low)
25,809 Detected genes Group median: 27,368 • 27.2%ile (≈ Median)
6 Mitochondrial fraction (%) Group median: 6 • 58.3%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

57.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.34
bar=donor   line=cohort median 		0.17 88.9%
FOXO3 Insulin/IGF-1 Signaling 10.58
bar=donor   line=cohort median 		12.92 25.1%
CETP Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.40 16.8%
SIRT6 Sirtuin Family 5.28
bar=donor   line=cohort median 		3.67 96.1%
SIRT1 Sirtuin Family 2.94
bar=donor   line=cohort median 		3.48 24.6%
SIRT3 Sirtuin Family 1.10
bar=donor   line=cohort median 		1.10 50.0%
IGF1R Insulin/IGF-1 Signaling 4.59
bar=donor   line=cohort median 		4.33 53.1%
KLOTHO Anti-aging 0.16
bar=donor   line=cohort median 		0.06 89.9%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.12
bar=donor   line=cohort median 		0.07 79.0%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 73.8%
IRS2 Insulin/IGF-1 Signaling 33.78
bar=donor   line=cohort median 		35.28 46.9%
TP53 Tumor Suppression 3.04
bar=donor   line=cohort median 		3.83 22.0%
SHC1 Signal Transduction 10.08
bar=donor   line=cohort median 		8.77 87.3%
ACE Signal Transduction 0.48
bar=donor   line=cohort median 		0.39 64.0%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 13,618.7 247,552
2 S100A9 ENSG00000163220 protein_coding 8,914.6 59,558
3 FTL ENSG00000087086 protein_coding 5,752.5 58,420
4 MT-CO1 ENSG00000198804 protein_coding 5,717.9 102,802
5 MT-CO2 ENSG00000198712 protein_coding 5,595.5 44,625
6 MT-RNR1 ENSG00000211459 Mt_rRNA 5,447.5 60,594
7 MT-ND1 ENSG00000198888 protein_coding 4,449.1 49,592
8 MT-CO3 ENSG00000198938 protein_coding 4,215.7 38,536
9 MT-ND3 ENSG00000198840 protein_coding 3,637.1 14,673
10 RPS28P7 ENSG00000227097 processed_pseudogene 3,557.3 8,710

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,280.2
bar=donor   line=cohort median 		1,223.7 1,385.4 43.3%
2 S100A9 protein_coding 8,914.6
bar=donor   line=cohort median 		7,732.1 9,235.1 47.4%
3 IL1B protein_coding 7.3
bar=donor   line=cohort median 		4.9 6.1 61.9%
4 CXCL8 protein_coding 262.5
bar=donor   line=cohort median 		197.4 207.4 60.9%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 10.3
bar=donor   line=cohort median 		2.9 2.4 95.1%
6 FCGR3B protein_coding 115.1
bar=donor   line=cohort median 		108.9 129.3 39.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 356.8
bar=donor   line=cohort median 		581.4 706.2 15.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 69.7
bar=donor   line=cohort median 		51.6 56.4 66.6%
9 CD3E protein_coding 31.8
bar=donor   line=cohort median 		38.1 37.7 31.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.0 3.1 29.8%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 209.6
bar=donor   line=cohort median 		252.2 281.6 27.2%
12 GNLY protein_coding 44.8
bar=donor   line=cohort median 		58.9 70.7 20.5%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 499.4
bar=donor   line=cohort median 		585.0 582.1 45.3%
14 HBA1 protein_coding 1,907.6
bar=donor   line=cohort median 		1,960.4 1,960.7 48.4%
15 HBA2 protein_coding 797.4
bar=donor   line=cohort median 		1,080.5 1,083.5 38.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,717.9
bar=donor   line=cohort median 		6,740.9 6,938.4 26.2%
17 MT-CO2 protein_coding 5,595.5
bar=donor   line=cohort median 		5,693.7 5,810.8 43.8%
18 MT-ND1 protein_coding 4,449.1
bar=donor   line=cohort median 		3,876.8 3,718.2 70.7%
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