GSM6881436

Dataset: gse221521 • Sample: DR group R_JS039 • Status: Diabetic retinopathy
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Quality Control Metrics

12,897,330 Total counts Group median: 12,498,211 • 60.9%ile (≈ Median)
27,564 Detected genes Group median: 27,368 • 79.0%ile (↑ High)
5 Mitochondrial fraction (%) Group median: 6 • 25.1%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

51.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.21
bar=donor   line=cohort median 		0.17 61.9%
FOXO3 Insulin/IGF-1 Signaling 7.95
bar=donor   line=cohort median 		12.92 13.7%
CETP Lipid Metabolism 0.42
bar=donor   line=cohort median 		0.40 55.7%
SIRT6 Sirtuin Family 4.94
bar=donor   line=cohort median 		3.67 90.4%
SIRT1 Sirtuin Family 2.51
bar=donor   line=cohort median 		3.48 9.1%
SIRT3 Sirtuin Family 1.06
bar=donor   line=cohort median 		1.10 41.7%
IGF1R Insulin/IGF-1 Signaling 0.80
bar=donor   line=cohort median 		4.33 8.0%
KLOTHO Anti-aging 0.08
bar=donor   line=cohort median 		0.06 58.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.23
bar=donor   line=cohort median 		0.07 92.5%
TERT Telomere Maintenance 0.00
bar=donor   line=cohort median 		0.01 18.7%
IRS2 Insulin/IGF-1 Signaling 18.42
bar=donor   line=cohort median 		35.28 14.3%
TP53 Tumor Suppression 4.88
bar=donor   line=cohort median 		3.83 75.9%
SHC1 Signal Transduction 10.53
bar=donor   line=cohort median 		8.77 92.5%
ACE Signal Transduction 0.76
bar=donor   line=cohort median 		0.39 89.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 11,298.2 227,173
2 S100A9 ENSG00000163220 protein_coding 7,784.4 57,528
3 AC005912.1 ENSG00000227081 processed_pseudogene 6,586.3 21,661
4 MT-CO2 ENSG00000198712 protein_coding 5,368.0 47,355
5 AC099560.2 ENSG00000234287 processed_pseudogene 5,141.4 16,909
6 RPL39P3 ENSG00000235174 processed_pseudogene 4,972.2 10,004
7 MT-RNR1 ENSG00000211459 Mt_rRNA 4,884.9 60,104
8 MT-CO1 ENSG00000198804 protein_coding 4,724.0 93,950
9 MT-TC ENSG00000210140 Mt_tRNA 4,280.9 3,644
10 FTL ENSG00000087086 protein_coding 4,108.9 46,158

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,930.4
bar=donor   line=cohort median 		1,223.7 1,385.4 73.8%
2 S100A9 protein_coding 7,784.4
bar=donor   line=cohort median 		7,732.1 9,235.1 39.1%
3 IL1B protein_coding 4.2
bar=donor   line=cohort median 		4.9 6.1 28.2%
4 CXCL8 protein_coding 139.1
bar=donor   line=cohort median 		197.4 207.4 29.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 10.9
bar=donor   line=cohort median 		2.9 2.4 96.6%
6 FCGR3B protein_coding 28.1
bar=donor   line=cohort median 		108.9 129.3 6.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 339.7
bar=donor   line=cohort median 		581.4 706.2 14.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 176.8
bar=donor   line=cohort median 		51.6 56.4 98.7%
9 CD3E protein_coding 50.9
bar=donor   line=cohort median 		38.1 37.7 78.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 2.4
bar=donor   line=cohort median 		3.0 3.1 29.3%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 562.3
bar=donor   line=cohort median 		252.2 281.6 93.0%
12 GNLY protein_coding 82.5
bar=donor   line=cohort median 		58.9 70.7 58.8%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 1,937.0
bar=donor   line=cohort median 		585.0 582.1 90.9%
14 HBA1 protein_coding 2,141.6
bar=donor   line=cohort median 		1,960.4 1,960.7 54.7%
15 HBA2 protein_coding 968.4
bar=donor   line=cohort median 		1,080.5 1,083.5 44.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 4,724.0
bar=donor   line=cohort median 		6,740.9 6,938.4 9.6%
17 MT-CO2 protein_coding 5,368.0
bar=donor   line=cohort median 		5,693.7 5,810.8 38.1%
18 MT-ND1 protein_coding 1,715.1
bar=donor   line=cohort median 		3,876.8 3,718.2 5.4%
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