GSM6881438

Dataset: gse221521 • Sample: DR group R_JS040 • Status: Diabetic retinopathy
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Quality Control Metrics

12,422,126 Total counts Group median: 12,498,211 • 41.7%ile (≈ Median)
27,306 Detected genes Group median: 27,368 • 72.3%ile (≈ Median)
7 Mitochondrial fraction (%) Group median: 6 • 74.4%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

49.5Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.13
bar=donor   line=cohort median 		0.17 41.2%
FOXO3 Insulin/IGF-1 Signaling 7.23
bar=donor   line=cohort median 		12.92 9.1%
CETP Lipid Metabolism 0.30
bar=donor   line=cohort median 		0.40 28.8%
SIRT6 Sirtuin Family 4.44
bar=donor   line=cohort median 		3.67 81.6%
SIRT1 Sirtuin Family 2.99
bar=donor   line=cohort median 		3.48 26.7%
SIRT3 Sirtuin Family 1.42
bar=donor   line=cohort median 		1.10 88.9%
IGF1R Insulin/IGF-1 Signaling 2.57
bar=donor   line=cohort median 		4.33 29.3%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 28.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.10
bar=donor   line=cohort median 		0.07 66.1%
TERT Telomere Maintenance 0.03
bar=donor   line=cohort median 		0.01 68.7%
IRS2 Insulin/IGF-1 Signaling 19.53
bar=donor   line=cohort median 		35.28 16.3%
TP53 Tumor Suppression 4.89
bar=donor   line=cohort median 		3.83 76.4%
SHC1 Signal Transduction 8.23
bar=donor   line=cohort median 		8.77 31.9%
ACE Signal Transduction 2.14
bar=donor   line=cohort median 		0.39 99.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 HBA1 ENSG00000206172 protein_coding 15,554.1 332,330
2 MT-RNR2 ENSG00000210082 Mt_rRNA 15,512.7 300,421
3 HBA2 ENSG00000188536 protein_coding 10,377.0 217,590
4 HBB ENSG00000244734 protein_coding 8,185.0 282,962
5 S100A9 ENSG00000163220 protein_coding 7,732.1 55,036
6 MT-CO2 ENSG00000198712 protein_coding 6,749.1 57,345
7 MT-CO3 ENSG00000198938 protein_coding 6,653.6 64,799
8 MT-RNR1 ENSG00000211459 Mt_rRNA 6,416.8 76,044
9 MT-ND3 ENSG00000198840 protein_coding 5,805.0 24,950
10 MT-CO1 ENSG00000198804 protein_coding 5,497.0 105,294

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,809.0
bar=donor   line=cohort median 		1,223.7 1,385.4 69.2%
2 S100A9 protein_coding 7,732.1
bar=donor   line=cohort median 		7,732.1 9,235.1 38.1%
3 IL1B protein_coding 3.1
bar=donor   line=cohort median 		4.9 6.1 18.4%
4 CXCL8 protein_coding 106.3
bar=donor   line=cohort median 		197.4 207.4 21.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 2.5
bar=donor   line=cohort median 		2.9 2.4 53.1%
6 FCGR3B protein_coding 69.0
bar=donor   line=cohort median 		108.9 129.3 16.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 614.4
bar=donor   line=cohort median 		581.4 706.2 41.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 100.5
bar=donor   line=cohort median 		51.6 56.4 87.8%
9 CD3E protein_coding 40.3
bar=donor   line=cohort median 		38.1 37.7 57.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 6.9
bar=donor   line=cohort median 		3.0 3.1 90.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 186.4
bar=donor   line=cohort median 		252.2 281.6 22.0%
12 GNLY protein_coding 46.8
bar=donor   line=cohort median 		58.9 70.7 24.1%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 8,185.0
bar=donor   line=cohort median 		585.0 582.1 99.7%
14 HBA1 protein_coding 15,554.1
bar=donor   line=cohort median 		1,960.4 1,960.7 98.2%
15 HBA2 protein_coding 10,377.0
bar=donor   line=cohort median 		1,080.5 1,083.5 99.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 5,497.0
bar=donor   line=cohort median 		6,740.9 6,938.4 21.5%
17 MT-CO2 protein_coding 6,749.1
bar=donor   line=cohort median 		5,693.7 5,810.8 67.1%
18 MT-ND1 protein_coding 3,637.6
bar=donor   line=cohort median 		3,876.8 3,718.2 46.9%
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