GSM6881439

Dataset: gse221521 • Sample: DR group R_JS041 • Status: Diabetic retinopathy
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Quality Control Metrics

12,017,022 Total counts Group median: 12,498,211 • 27.2%ile (≈ Median)
28,338 Detected genes Group median: 27,368 • 91.5%ile (↑ High)
7 Mitochondrial fraction (%) Group median: 6 • 70.2%ile (≈ Median)

FPKM/count values are derived from the public processed GSE221521 expression matrix.

Longevity Gene Set (15)

64.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (FPKM)vs CohortCohort Median%ile
APOE Lipid Metabolism 0.24
bar=donor   line=cohort median 		0.17 72.3%
FOXO3 Insulin/IGF-1 Signaling 10.77
bar=donor   line=cohort median 		12.92 27.2%
CETP Lipid Metabolism 0.63
bar=donor   line=cohort median 		0.40 85.2%
SIRT6 Sirtuin Family 3.63
bar=donor   line=cohort median 		3.67 46.9%
SIRT1 Sirtuin Family 2.67
bar=donor   line=cohort median 		3.48 13.7%
SIRT3 Sirtuin Family 1.37
bar=donor   line=cohort median 		1.10 85.8%
IGF1R Insulin/IGF-1 Signaling 5.18
bar=donor   line=cohort median 		4.33 65.5%
KLOTHO Anti-aging 0.04
bar=donor   line=cohort median 		0.06 29.8%
APOC3 Lipid Metabolism 0.00
bar=donor   line=cohort median 		0.00 48.5%
IL6 Inflammation 0.08
bar=donor   line=cohort median 		0.07 59.8%
TERT Telomere Maintenance 0.06
bar=donor   line=cohort median 		0.01 94.6%
IRS2 Insulin/IGF-1 Signaling 42.59
bar=donor   line=cohort median 		35.28 61.4%
TP53 Tumor Suppression 6.58
bar=donor   line=cohort median 		3.83 96.6%
SHC1 Signal Transduction 11.17
bar=donor   line=cohort median 		8.77 98.2%
ACE Signal Transduction 0.60
bar=donor   line=cohort median 		0.39 81.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (FPKM)Count
1 MT-RNR2 ENSG00000210082 Mt_rRNA 12,179.5 228,177
2 MT-CO1 ENSG00000198804 protein_coding 6,326.6 117,233
3 MT-RNR1 ENSG00000211459 Mt_rRNA 6,061.9 69,495
4 MT-ATP6 ENSG00000198899 protein_coding 6,014.4 49,219
5 S100A9 ENSG00000163220 protein_coding 5,991.1 41,253
6 MT-CO2 ENSG00000198712 protein_coding 5,830.4 47,924
7 MT-ND3 ENSG00000198840 protein_coding 5,334.2 22,179
8 MT-CO3 ENSG00000198938 protein_coding 4,642.4 43,738
9 MT-ND1 ENSG00000198888 protein_coding 4,221.7 48,500
10 FTL ENSG00000087086 protein_coding 3,803.0 39,805

Immune Marker Gene Expression (18 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 protein_coding 1,171.2
bar=donor   line=cohort median 		1,223.7 1,385.4 35.5%
2 S100A9 protein_coding 5,991.1
bar=donor   line=cohort median 		7,732.1 9,235.1 21.5%
3 IL1B protein_coding 6.2
bar=donor   line=cohort median 		4.9 6.1 52.1%
4 CXCL8 protein_coding 67.2
bar=donor   line=cohort median 		197.4 207.4 11.1%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO protein_coding 7.4
bar=donor   line=cohort median 		2.9 2.4 88.9%
6 FCGR3B protein_coding 88.7
bar=donor   line=cohort median 		108.9 129.3 27.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ protein_coding 321.3
bar=donor   line=cohort median 		581.4 706.2 13.2%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D protein_coding 51.6
bar=donor   line=cohort median 		51.6 56.4 43.8%
9 CD3E protein_coding 36.8
bar=donor   line=cohort median 		38.1 37.7 46.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 protein_coding 5.0
bar=donor   line=cohort median 		3.0 3.1 82.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 protein_coding 116.3
bar=donor   line=cohort median 		252.2 281.6 4.9%
12 GNLY protein_coding 22.6
bar=donor   line=cohort median 		58.9 70.7 3.9%

Hemoglobin / erythroid (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
13 HBB protein_coding 862.7
bar=donor   line=cohort median 		585.0 582.1 68.1%
14 HBA1 protein_coding 1,531.0
bar=donor   line=cohort median 		1,960.4 1,960.7 38.1%
15 HBA2 protein_coding 1,154.3
bar=donor   line=cohort median 		1,080.5 1,083.5 53.6%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 protein_coding 6,326.6
bar=donor   line=cohort median 		6,740.9 6,938.4 37.0%
17 MT-CO2 protein_coding 5,830.4
bar=donor   line=cohort median 		5,693.7 5,810.8 50.5%
18 MT-ND1 protein_coding 4,221.7
bar=donor   line=cohort median 		3,876.8 3,718.2 66.6%
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