GSM8077449

Dataset: gse255685 • Sample: YZ1002 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 47.8%ile (≈ Median)
22,340 Genes with score > 0 Group median: 22,375 • 9.5%ile (↓ Low)
0 Median expression score Group median: 0 • 14.2%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

43.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.72
bar=donor   line=cohort median 		2.02 3.4%
FOXO3 Insulin/IGF-1 Signaling 9.56
bar=donor   line=cohort median 		9.99 5.2%
CETP Lipid Metabolism 6.90
bar=donor   line=cohort median 		5.05 99.8%
SIRT6 Sirtuin Family 8.67
bar=donor   line=cohort median 		8.34 90.1%
SIRT1 Sirtuin Family 8.53
bar=donor   line=cohort median 		8.72 22.0%
SIRT3 Sirtuin Family 7.26
bar=donor   line=cohort median 		7.49 11.3%
IGF1R Insulin/IGF-1 Signaling 9.43
bar=donor   line=cohort median 		10.21 3.8%
KLOTHO Anti-aging 2.94
bar=donor   line=cohort median 		2.51 93.7%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 61.1%
IL6 Inflammation 1.00
bar=donor   line=cohort median 		1.16 12.0%
TERT Telomere Maintenance 1.29
bar=donor   line=cohort median 		1.51 5.2%
IRS2 Insulin/IGF-1 Signaling 8.75
bar=donor   line=cohort median 		9.81 0.2%
TP53 Tumor Suppression 9.25
bar=donor   line=cohort median 		8.92 94.8%
SHC1 Signal Transduction 9.93
bar=donor   line=cohort median 		9.35 99.8%
ACE Signal Transduction 4.68
bar=donor   line=cohort median 		4.64 54.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MTCO2P12 22.4 0
2 HLA-C 16.8 0
3 B2M 16.8 0
4 ACTB 16.7 0
5 MT-RNR2 16.4 0
6 HLA-B 16.3 0
7 MT-CO1 16.2 0
8 HLA-E 16.2 0
9 CSF3R 16.0 0
10 EEF1A1 16.0 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.9
bar=donor   line=cohort median 		13.8 14.2 8.4%
2 S100A9 15.0
bar=donor   line=cohort median 		15.3 15.5 13.4%
3 IL1B 10.2
bar=donor   line=cohort median 		9.5 9.3 93.4%
4 CXCL8 8.2
bar=donor   line=cohort median 		10.6 11.4 2.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.7
bar=donor   line=cohort median 		6.0 6.1 78.7%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.6 14.7 85.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 15.1
bar=donor   line=cohort median 		14.3 14.3 96.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.7
bar=donor   line=cohort median 		10.2 10.4 3.8%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 50.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 9.8
bar=donor   line=cohort median 		11.0 10.9 0.2%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.4
bar=donor   line=cohort median 		11.7 11.7 85.1%
12 GNLY 12.3
bar=donor   line=cohort median 		12.0 12.1 61.5%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.2
bar=donor   line=cohort median 		16.4 16.4 13.4%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.2 15.3 6.6%
18 MT-ND1 14.8
bar=donor   line=cohort median 		15.0 15.2 7.0%
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