GSM8077450

Dataset: gse255685 • Sample: YZ1005 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 26.3%ile (≈ Median)
22,410 Genes with score > 0 Group median: 22,375 • 84.1%ile (↑ High)
0 Median expression score Group median: 0 • 60.4%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

50.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.69
bar=donor   line=cohort median 		2.02 0.9%
FOXO3 Insulin/IGF-1 Signaling 9.76
bar=donor   line=cohort median 		9.99 21.7%
CETP Lipid Metabolism 5.51
bar=donor   line=cohort median 		5.05 91.2%
SIRT6 Sirtuin Family 8.48
bar=donor   line=cohort median 		8.34 74.7%
SIRT1 Sirtuin Family 8.41
bar=donor   line=cohort median 		8.72 11.3%
SIRT3 Sirtuin Family 7.86
bar=donor   line=cohort median 		7.49 98.4%
IGF1R Insulin/IGF-1 Signaling 10.42
bar=donor   line=cohort median 		10.21 72.9%
KLOTHO Anti-aging 2.63
bar=donor   line=cohort median 		2.51 67.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 23.1%
IL6 Inflammation 1.07
bar=donor   line=cohort median 		1.16 23.1%
TERT Telomere Maintenance 1.43
bar=donor   line=cohort median 		1.51 31.0%
IRS2 Insulin/IGF-1 Signaling 9.35
bar=donor   line=cohort median 		9.81 13.1%
TP53 Tumor Suppression 9.26
bar=donor   line=cohort median 		8.92 95.2%
SHC1 Signal Transduction 9.53
bar=donor   line=cohort median 		9.35 90.1%
ACE Signal Transduction 4.54
bar=donor   line=cohort median 		4.64 40.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.4 0
2 MT-CO1 16.3 0
3 EEF1A1 16.3 0
4 B2M 16.2 0
5 MT-RNR2 16.0 0
6 HLA-B 15.9 0
7 HLA-C 15.8 0
8 HLA-E 15.7 0
9 CSF3R 15.7 0
10 FKBP8 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.6
bar=donor   line=cohort median 		13.8 14.2 5.6%
2 S100A9 14.9
bar=donor   line=cohort median 		15.3 15.5 9.5%
3 IL1B 9.6
bar=donor   line=cohort median 		9.5 9.3 65.4%
4 CXCL8 8.1
bar=donor   line=cohort median 		10.6 11.4 0.2%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.0 6.1 9.1%
6 FCGR3B 13.9
bar=donor   line=cohort median 		14.6 14.7 7.7%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.3
bar=donor   line=cohort median 		14.3 14.3 46.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.1
bar=donor   line=cohort median 		10.2 10.4 15.9%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 73.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.3
bar=donor   line=cohort median 		11.0 10.9 85.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.0
bar=donor   line=cohort median 		11.7 11.7 69.7%
12 GNLY 12.0
bar=donor   line=cohort median 		12.0 12.1 41.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 16.7%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.2 15.3 4.8%
18 MT-ND1 14.8
bar=donor   line=cohort median 		15.0 15.2 6.6%
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