GSM8077451

Dataset: gse255685 • Sample: YZ1045 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 21.0%ile (↓ Low)
22,338 Genes with score > 0 Group median: 22,375 • 8.6%ile (↓ Low)
0 Median expression score Group median: 0 • 10.6%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

60.7Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.73
bar=donor   line=cohort median 		2.02 5.2%
FOXO3 Insulin/IGF-1 Signaling 10.27
bar=donor   line=cohort median 		9.99 88.4%
CETP Lipid Metabolism 5.34
bar=donor   line=cohort median 		5.05 82.6%
SIRT6 Sirtuin Family 8.63
bar=donor   line=cohort median 		8.34 88.7%
SIRT1 Sirtuin Family 8.28
bar=donor   line=cohort median 		8.72 5.6%
SIRT3 Sirtuin Family 7.74
bar=donor   line=cohort median 		7.49 90.1%
IGF1R Insulin/IGF-1 Signaling 10.68
bar=donor   line=cohort median 		10.21 94.1%
KLOTHO Anti-aging 2.37
bar=donor   line=cohort median 		2.51 29.6%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 69.0%
IL6 Inflammation 1.01
bar=donor   line=cohort median 		1.16 13.4%
TERT Telomere Maintenance 1.49
bar=donor   line=cohort median 		1.51 44.6%
IRS2 Insulin/IGF-1 Signaling 10.22
bar=donor   line=cohort median 		9.81 73.3%
TP53 Tumor Suppression 9.21
bar=donor   line=cohort median 		8.92 93.4%
SHC1 Signal Transduction 9.80
bar=donor   line=cohort median 		9.35 99.1%
ACE Signal Transduction 4.47
bar=donor   line=cohort median 		4.64 33.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 17.0 0
2 HLA-C 16.8 0
3 CSF3R 16.5 0
4 MT-CO1 16.3 0
5 MT-RNR2 16.3 0
6 HLA-E 16.2 0
7 HLA-B 16.2 0
8 B2M 15.9 0
9 TXNIP 15.9 0
10 FKBP8 15.8 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.5
bar=donor   line=cohort median 		13.8 14.2 4.8%
2 S100A9 15.0
bar=donor   line=cohort median 		15.3 15.5 17.0%
3 IL1B 10.0
bar=donor   line=cohort median 		9.5 9.3 87.3%
4 CXCL8 8.7
bar=donor   line=cohort median 		10.6 11.4 7.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.9
bar=donor   line=cohort median 		6.0 6.1 38.5%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.6 14.7 86.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.3
bar=donor   line=cohort median 		14.3 14.3 43.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.4
bar=donor   line=cohort median 		10.2 10.4 0.9%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 41.4%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.8
bar=donor   line=cohort median 		11.0 10.9 32.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.1
bar=donor   line=cohort median 		11.7 11.7 6.6%
12 GNLY 11.4
bar=donor   line=cohort median 		12.0 12.1 7.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 17.4%
17 MT-CO2 15.0
bar=donor   line=cohort median 		15.2 15.3 12.7%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.0 15.2 17.4%
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