GSM8077452

Dataset: gse255685 • Sample: YZ1077 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 0.9%ile (↓ Low)
22,355 Genes with score > 0 Group median: 22,378 • 19.7%ile (↓ Low)
0 Median expression score Group median: 0 • 16.3%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

56.0Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.74
bar=donor   line=cohort median 		2.02 7.0%
FOXO3 Insulin/IGF-1 Signaling 9.99
bar=donor   line=cohort median 		9.99 49.6%
CETP Lipid Metabolism 5.50
bar=donor   line=cohort median 		5.05 90.5%
SIRT6 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.34 46.4%
SIRT1 Sirtuin Family 8.60
bar=donor   line=cohort median 		8.72 35.0%
SIRT3 Sirtuin Family 7.53
bar=donor   line=cohort median 		7.49 56.8%
IGF1R Insulin/IGF-1 Signaling 10.56
bar=donor   line=cohort median 		10.21 86.6%
KLOTHO Anti-aging 2.90
bar=donor   line=cohort median 		2.51 91.2%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 4.1%
IL6 Inflammation 1.24
bar=donor   line=cohort median 		1.16 66.1%
TERT Telomere Maintenance 1.33
bar=donor   line=cohort median 		1.51 11.7%
IRS2 Insulin/IGF-1 Signaling 9.73
bar=donor   line=cohort median 		9.81 41.8%
TP53 Tumor Suppression 9.17
bar=donor   line=cohort median 		8.92 89.4%
SHC1 Signal Transduction 9.69
bar=donor   line=cohort median 		9.35 97.7%
ACE Signal Transduction 4.81
bar=donor   line=cohort median 		4.64 66.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.7 0
2 MT-CO1 16.3 0
3 HLA-C 16.3 0
4 CSF3R 16.1 0
5 HLA-E 16.0 0
6 MT-RNR2 15.9 0
7 HLA-B 15.9 0
8 B2M 15.7 0
9 EEF1A1 15.6 0
10 TXNIP 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.0
bar=donor   line=cohort median 		14.2 14.2 1.3%
2 S100A9 14.6
bar=donor   line=cohort median 		15.4 15.5 4.5%
3 IL1B 10.1
bar=donor   line=cohort median 		9.5 9.3 89.4%
4 CXCL8 8.2
bar=donor   line=cohort median 		10.3 11.4 1.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.1 6.1 12.4%
6 FCGR3B 14.9
bar=donor   line=cohort median 		14.7 14.7 67.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.9
bar=donor   line=cohort median 		14.4 14.3 17.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.4
bar=donor   line=cohort median 		10.3 10.4 1.3%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 63.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.6
bar=donor   line=cohort median 		10.9 10.9 17.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.7
bar=donor   line=cohort median 		11.5 11.7 50.4%
12 GNLY 12.0
bar=donor   line=cohort median 		12.0 12.1 38.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 23.8%
17 MT-CO2 14.9
bar=donor   line=cohort median 		15.3 15.3 5.6%
18 MT-ND1 14.7
bar=donor   line=cohort median 		15.2 15.2 3.4%
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