GSM8077453

Dataset: gse255685 • Sample: YZ1083 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 41.4%ile (≈ Median)
22,416 Genes with score > 0 Group median: 22,375 • 87.6%ile (↑ High)
0 Median expression score Group median: 0 • 69.4%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

54.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.08
bar=donor   line=cohort median 		2.02 60.4%
FOXO3 Insulin/IGF-1 Signaling 9.68
bar=donor   line=cohort median 		9.99 12.7%
CETP Lipid Metabolism 5.50
bar=donor   line=cohort median 		5.05 90.1%
SIRT6 Sirtuin Family 8.32
bar=donor   line=cohort median 		8.34 45.7%
SIRT1 Sirtuin Family 8.61
bar=donor   line=cohort median 		8.72 36.4%
SIRT3 Sirtuin Family 7.94
bar=donor   line=cohort median 		7.49 99.8%
IGF1R Insulin/IGF-1 Signaling 10.32
bar=donor   line=cohort median 		10.21 60.0%
KLOTHO Anti-aging 2.43
bar=donor   line=cohort median 		2.51 39.6%
APOC3 Lipid Metabolism -2.12
bar=donor   line=cohort median 		-2.11 2.3%
IL6 Inflammation 1.04
bar=donor   line=cohort median 		1.16 17.7%
TERT Telomere Maintenance 1.83
bar=donor   line=cohort median 		1.51 92.7%
IRS2 Insulin/IGF-1 Signaling 9.46
bar=donor   line=cohort median 		9.81 19.2%
TP53 Tumor Suppression 9.26
bar=donor   line=cohort median 		8.92 95.5%
SHC1 Signal Transduction 9.42
bar=donor   line=cohort median 		9.35 73.7%
ACE Signal Transduction 4.84
bar=donor   line=cohort median 		4.64 70.1%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 EEF1A1 16.4 0
2 ACTB 16.3 0
3 B2M 16.2 0
4 MT-RNR2 16.2 0
5 HLA-C 16.1 0
6 MT-CO1 16.0 0
7 HLA-E 15.7 0
8 CSF3R 15.7 0
9 HLA-B 15.6 0
10 CD74 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.6
bar=donor   line=cohort median 		13.8 14.2 6.3%
2 S100A9 14.6
bar=donor   line=cohort median 		15.3 15.5 3.0%
3 IL1B 8.8
bar=donor   line=cohort median 		9.5 9.3 26.0%
4 CXCL8 8.8
bar=donor   line=cohort median 		10.6 11.4 8.4%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.0 6.1 5.9%
6 FCGR3B 14.4
bar=donor   line=cohort median 		14.6 14.7 23.5%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.9
bar=donor   line=cohort median 		14.3 14.3 18.8%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.0
bar=donor   line=cohort median 		10.2 10.4 14.5%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 68.3%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.7
bar=donor   line=cohort median 		11.0 10.9 99.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.6
bar=donor   line=cohort median 		11.7 11.7 40.3%
12 GNLY 11.9
bar=donor   line=cohort median 		12.0 12.1 32.4%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.0
bar=donor   line=cohort median 		16.4 16.4 0.2%
17 MT-CO2 14.8
bar=donor   line=cohort median 		15.2 15.3 3.0%
18 MT-ND1 14.4
bar=donor   line=cohort median 		15.0 15.2 1.3%
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