GSM8077454

Dataset: gse255685 • Sample: YZ1092 • Status: MDD with drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 21.7%ile (↓ Low)
22,379 Genes with score > 0 Group median: 22,378 • 51.8%ile (≈ Median)
0 Median expression score Group median: 0 • 59.3%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

73.1Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.06
bar=donor   line=cohort median 		2.02 57.5%
FOXO3 Insulin/IGF-1 Signaling 10.23
bar=donor   line=cohort median 		9.99 85.8%
CETP Lipid Metabolism 5.37
bar=donor   line=cohort median 		5.05 85.1%
SIRT6 Sirtuin Family 8.51
bar=donor   line=cohort median 		8.34 79.0%
SIRT1 Sirtuin Family 8.58
bar=donor   line=cohort median 		8.72 32.1%
SIRT3 Sirtuin Family 7.81
bar=donor   line=cohort median 		7.49 95.9%
IGF1R Insulin/IGF-1 Signaling 11.13
bar=donor   line=cohort median 		10.21 99.8%
KLOTHO Anti-aging 2.42
bar=donor   line=cohort median 		2.51 37.5%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 26.3%
IL6 Inflammation 1.42
bar=donor   line=cohort median 		1.16 88.0%
TERT Telomere Maintenance 1.75
bar=donor   line=cohort median 		1.51 88.0%
IRS2 Insulin/IGF-1 Signaling 9.80
bar=donor   line=cohort median 		9.81 48.6%
TP53 Tumor Suppression 9.27
bar=donor   line=cohort median 		8.92 96.6%
SHC1 Signal Transduction 9.70
bar=donor   line=cohort median 		9.35 98.4%
ACE Signal Transduction 4.91
bar=donor   line=cohort median 		4.64 77.2%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 ACTB 16.9 0
2 MT-CO1 16.5 0
3 HLA-C 16.4 0
4 CSF3R 16.4 0
5 HLA-E 16.2 0
6 MT-RNR2 16.1 0
7 HLA-B 16.0 0
8 B2M 15.7 0
9 EEF1A1 15.6 0
10 FTL 15.5 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 12.4
bar=donor   line=cohort median 		14.2 14.2 4.1%
2 S100A9 15.0
bar=donor   line=cohort median 		15.4 15.5 13.1%
3 IL1B 10.3
bar=donor   line=cohort median 		9.5 9.3 94.4%
4 CXCL8 8.3
bar=donor   line=cohort median 		10.3 11.4 2.7%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.9
bar=donor   line=cohort median 		6.1 6.1 41.0%
6 FCGR3B 15.2
bar=donor   line=cohort median 		14.7 14.7 87.3%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.5
bar=donor   line=cohort median 		14.4 14.3 62.9%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.3
bar=donor   line=cohort median 		10.3 10.4 0.5%
9 CD3E 12.0
bar=donor   line=cohort median 		11.9 12.0 52.9%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.5
bar=donor   line=cohort median 		10.9 10.9 15.9%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.6
bar=donor   line=cohort median 		11.5 11.7 41.0%
12 GNLY 12.6
bar=donor   line=cohort median 		12.0 12.1 81.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 59.7%
17 MT-CO2 14.8
bar=donor   line=cohort median 		15.3 15.3 3.8%
18 MT-ND1 14.7
bar=donor   line=cohort median 		15.2 15.2 5.9%
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