GSM8077455

Dataset: gse255685 • Sample: YZ161 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 56.1%ile (≈ Median)
22,385 Genes with score > 0 Group median: 22,375 • 61.8%ile (≈ Median)
0 Median expression score Group median: 0 • 69.0%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

57.6Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.79
bar=donor   line=cohort median 		2.02 11.3%
FOXO3 Insulin/IGF-1 Signaling 10.13
bar=donor   line=cohort median 		9.99 74.4%
CETP Lipid Metabolism 5.22
bar=donor   line=cohort median 		5.05 72.9%
SIRT6 Sirtuin Family 8.20
bar=donor   line=cohort median 		8.34 19.2%
SIRT1 Sirtuin Family 8.90
bar=donor   line=cohort median 		8.72 83.3%
SIRT3 Sirtuin Family 7.55
bar=donor   line=cohort median 		7.49 61.1%
IGF1R Insulin/IGF-1 Signaling 10.65
bar=donor   line=cohort median 		10.21 91.9%
KLOTHO Anti-aging 2.98
bar=donor   line=cohort median 		2.51 95.2%
APOC3 Lipid Metabolism -2.08
bar=donor   line=cohort median 		-2.11 95.2%
IL6 Inflammation 1.24
bar=donor   line=cohort median 		1.16 65.4%
TERT Telomere Maintenance 1.28
bar=donor   line=cohort median 		1.51 2.3%
IRS2 Insulin/IGF-1 Signaling 9.65
bar=donor   line=cohort median 		9.81 33.5%
TP53 Tumor Suppression 9.08
bar=donor   line=cohort median 		8.92 76.2%
SHC1 Signal Transduction 9.35
bar=donor   line=cohort median 		9.35 48.9%
ACE Signal Transduction 4.46
bar=donor   line=cohort median 		4.64 32.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.5 0
2 B2M 16.8 0
3 MT-CO1 16.6 0
4 ACTB 16.6 0
5 EEF1A1 16.5 0
6 MT-RNR1 16.0 0
7 FTL 15.7 0
8 CSF3R 15.7 0
9 HLA-E 15.7 0
10 HLA-B 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.8
bar=donor   line=cohort median 		13.8 14.2 24.2%
2 S100A9 15.3
bar=donor   line=cohort median 		15.3 15.5 29.6%
3 IL1B 9.6
bar=donor   line=cohort median 		9.5 9.3 68.3%
4 CXCL8 9.4
bar=donor   line=cohort median 		10.6 11.4 16.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.8
bar=donor   line=cohort median 		6.0 6.1 81.5%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.6 14.7 42.1%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.2
bar=donor   line=cohort median 		14.3 14.3 40.3%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 9.9
bar=donor   line=cohort median 		10.2 10.4 8.1%
9 CD3E 11.5
bar=donor   line=cohort median 		11.9 12.0 0.2%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.2
bar=donor   line=cohort median 		11.0 10.9 79.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.2
bar=donor   line=cohort median 		11.7 11.7 12.0%
12 GNLY 11.6
bar=donor   line=cohort median 		12.0 12.1 15.2%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 81.2%
17 MT-CO2 15.4
bar=donor   line=cohort median 		15.2 15.3 53.9%
18 MT-ND1 15.2
bar=donor   line=cohort median 		15.0 15.2 41.8%
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