GSM8077456

Dataset: gse255685 • Sample: YZ164 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 53.9%ile (≈ Median)
22,390 Genes with score > 0 Group median: 22,375 • 67.7%ile (≈ Median)
0 Median expression score Group median: 0 • 53.9%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

46.4Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.76
bar=donor   line=cohort median 		2.02 8.4%
FOXO3 Insulin/IGF-1 Signaling 9.91
bar=donor   line=cohort median 		9.99 37.1%
CETP Lipid Metabolism 5.04
bar=donor   line=cohort median 		5.05 48.9%
SIRT6 Sirtuin Family 8.23
bar=donor   line=cohort median 		8.34 25.3%
SIRT1 Sirtuin Family 8.76
bar=donor   line=cohort median 		8.72 57.9%
SIRT3 Sirtuin Family 7.24
bar=donor   line=cohort median 		7.49 8.8%
IGF1R Insulin/IGF-1 Signaling 10.43
bar=donor   line=cohort median 		10.21 74.0%
KLOTHO Anti-aging 2.50
bar=donor   line=cohort median 		2.51 48.9%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 12.4%
IL6 Inflammation 1.33
bar=donor   line=cohort median 		1.16 82.6%
TERT Telomere Maintenance 1.61
bar=donor   line=cohort median 		1.51 71.9%
IRS2 Insulin/IGF-1 Signaling 9.49
bar=donor   line=cohort median 		9.81 22.0%
TP53 Tumor Suppression 9.18
bar=donor   line=cohort median 		8.92 90.9%
SHC1 Signal Transduction 9.40
bar=donor   line=cohort median 		9.35 66.9%
ACE Signal Transduction 4.54
bar=donor   line=cohort median 		4.64 40.7%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.2 0
2 B2M 16.7 0
3 EEF1A1 16.6 0
4 ACTB 16.4 0
5 MT-CO1 16.3 0
6 MT-RNR1 15.7 0
7 HLA-B 15.6 0
8 HLA-E 15.5 0
9 FTL 15.4 0
10 CSF3R 15.3 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.6
bar=donor   line=cohort median 		13.8 14.2 18.1%
2 S100A9 15.1
bar=donor   line=cohort median 		15.3 15.5 17.7%
3 IL1B 9.3
bar=donor   line=cohort median 		9.5 9.3 51.8%
4 CXCL8 9.0
bar=donor   line=cohort median 		10.6 11.4 11.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.2
bar=donor   line=cohort median 		6.0 6.1 1.3%
6 FCGR3B 14.5
bar=donor   line=cohort median 		14.6 14.7 30.6%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 14.1
bar=donor   line=cohort median 		14.3 14.3 29.6%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.4
bar=donor   line=cohort median 		10.2 10.4 55.0%
9 CD3E 11.9
bar=donor   line=cohort median 		11.9 12.0 33.5%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.2
bar=donor   line=cohort median 		11.0 10.9 84.1%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.1
bar=donor   line=cohort median 		11.7 11.7 71.9%
12 GNLY 12.6
bar=donor   line=cohort median 		12.0 12.1 79.0%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.3
bar=donor   line=cohort median 		16.4 16.4 26.3%
17 MT-CO2 14.7
bar=donor   line=cohort median 		15.2 15.3 2.3%
18 MT-ND1 14.8
bar=donor   line=cohort median 		15.0 15.2 9.5%
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