GSM8077457

Dataset: gse255685 • Sample: YZ166 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 28.1%ile (≈ Median)
22,358 Genes with score > 0 Group median: 22,375 • 24.6%ile (↓ Low)
0 Median expression score Group median: 0 • 52.5%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

45.8Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.01
bar=donor   line=cohort median 		2.02 48.9%
FOXO3 Insulin/IGF-1 Signaling 9.98
bar=donor   line=cohort median 		9.99 47.1%
CETP Lipid Metabolism 5.27
bar=donor   line=cohort median 		5.05 78.0%
SIRT6 Sirtuin Family 8.23
bar=donor   line=cohort median 		8.34 26.0%
SIRT1 Sirtuin Family 8.78
bar=donor   line=cohort median 		8.72 63.6%
SIRT3 Sirtuin Family 7.23
bar=donor   line=cohort median 		7.49 8.4%
IGF1R Insulin/IGF-1 Signaling 10.04
bar=donor   line=cohort median 		10.21 33.9%
KLOTHO Anti-aging 2.19
bar=donor   line=cohort median 		2.51 7.4%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 8.4%
IL6 Inflammation 1.48
bar=donor   line=cohort median 		1.16 92.3%
TERT Telomere Maintenance 1.34
bar=donor   line=cohort median 		1.51 12.4%
IRS2 Insulin/IGF-1 Signaling 9.62
bar=donor   line=cohort median 		9.81 30.3%
TP53 Tumor Suppression 9.03
bar=donor   line=cohort median 		8.92 70.8%
SHC1 Signal Transduction 9.46
bar=donor   line=cohort median 		9.35 80.8%
ACE Signal Transduction 4.93
bar=donor   line=cohort median 		4.64 78.3%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.0 0
2 B2M 16.8 0
3 EEF1A1 16.6 0
4 MT-CO1 16.5 0
5 ACTB 16.4 0
6 HLA-C 16.1 0
7 HLA-E 15.7 0
8 MT-RNR1 15.6 0
9 HLA-B 15.6 0
10 CSF3R 15.4 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.5
bar=donor   line=cohort median 		13.8 14.2 14.9%
2 S100A9 15.0
bar=donor   line=cohort median 		15.3 15.5 16.7%
3 IL1B 9.2
bar=donor   line=cohort median 		9.5 9.3 44.3%
4 CXCL8 10.7
bar=donor   line=cohort median 		10.6 11.4 36.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.5
bar=donor   line=cohort median 		6.0 6.1 8.1%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.6 14.7 41.8%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.8
bar=donor   line=cohort median 		14.3 14.3 9.1%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.2 10.4 70.1%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 75.8%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 10.7
bar=donor   line=cohort median 		11.0 10.9 24.6%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.5
bar=donor   line=cohort median 		11.7 11.7 89.4%
12 GNLY 13.0
bar=donor   line=cohort median 		12.0 12.1 90.9%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.5
bar=donor   line=cohort median 		16.4 16.4 63.6%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.2 15.3 17.0%
18 MT-ND1 14.9
bar=donor   line=cohort median 		15.0 15.2 10.9%
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