GSM8077458

Dataset: gse255685 • Sample: YZ178 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 38.2%ile (≈ Median)
22,377 Genes with score > 0 Group median: 22,375 • 48.2%ile (≈ Median)
0 Median expression score Group median: 0 • 37.5%ile (≈ Median)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

46.2Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 1.80
bar=donor   line=cohort median 		2.02 15.2%
FOXO3 Insulin/IGF-1 Signaling 9.91
bar=donor   line=cohort median 		9.99 37.8%
CETP Lipid Metabolism 5.16
bar=donor   line=cohort median 		5.05 66.9%
SIRT6 Sirtuin Family 8.41
bar=donor   line=cohort median 		8.34 64.7%
SIRT1 Sirtuin Family 8.79
bar=donor   line=cohort median 		8.72 64.0%
SIRT3 Sirtuin Family 7.46
bar=donor   line=cohort median 		7.49 42.8%
IGF1R Insulin/IGF-1 Signaling 10.42
bar=donor   line=cohort median 		10.21 73.3%
KLOTHO Anti-aging 2.47
bar=donor   line=cohort median 		2.51 46.8%
APOC3 Lipid Metabolism -2.11
bar=donor   line=cohort median 		-2.11 50.7%
IL6 Inflammation 1.09
bar=donor   line=cohort median 		1.16 32.1%
TERT Telomere Maintenance 1.37
bar=donor   line=cohort median 		1.51 20.6%
IRS2 Insulin/IGF-1 Signaling 9.44
bar=donor   line=cohort median 		9.81 16.7%
TP53 Tumor Suppression 8.94
bar=donor   line=cohort median 		8.92 53.6%
SHC1 Signal Transduction 9.36
bar=donor   line=cohort median 		9.35 53.6%
ACE Signal Transduction 4.68
bar=donor   line=cohort median 		4.64 53.9%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.4 0
2 B2M 16.7 0
3 EEF1A1 16.6 0
4 ACTB 16.5 0
5 MT-CO1 16.4 0
6 MT-RNR1 15.9 0
7 HLA-C 15.8 0
8 HLA-B 15.8 0
9 CSF3R 15.6 0
10 FTL 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 14.0
bar=donor   line=cohort median 		13.8 14.2 40.3%
2 S100A9 15.5
bar=donor   line=cohort median 		15.3 15.5 47.5%
3 IL1B 9.9
bar=donor   line=cohort median 		9.5 9.3 81.9%
4 CXCL8 10.3
bar=donor   line=cohort median 		10.6 11.4 31.0%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 6.1
bar=donor   line=cohort median 		6.0 6.1 50.4%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.6 14.7 43.2%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.8
bar=donor   line=cohort median 		14.3 14.3 13.4%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.2
bar=donor   line=cohort median 		10.2 10.4 32.4%
9 CD3E 11.7
bar=donor   line=cohort median 		11.9 12.0 12.0%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		11.0 10.9 70.4%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 11.5
bar=donor   line=cohort median 		11.7 11.7 34.6%
12 GNLY 12.1
bar=donor   line=cohort median 		12.0 12.1 45.3%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.4
bar=donor   line=cohort median 		16.4 16.4 47.1%
17 MT-CO2 15.1
bar=donor   line=cohort median 		15.2 15.3 26.7%
18 MT-ND1 15.0
bar=donor   line=cohort median 		15.0 15.2 18.8%
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