GSM8077459

Dataset: gse255685 • Sample: YZ188 • Status: MDD without drug therapy
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Quality Control Metrics

2 Mean expression score Group median: 2 • 12.0%ile (↓ Low)
22,347 Genes with score > 0 Group median: 22,375 • 12.4%ile (↓ Low)
0 Median expression score Group median: 0 • 9.9%ile (↓ Low)

GSE255685 provides per-sample processed expression-score files; values are not raw counts.

Longevity Gene Set (15)

45.3Longevity Score (mean cohort rank, 15/15 genes)
GenePathwayExpression (rlog)vs CohortCohort Median%ile
APOE Lipid Metabolism 2.04
bar=donor   line=cohort median 		2.02 52.5%
FOXO3 Insulin/IGF-1 Signaling 9.69
bar=donor   line=cohort median 		9.99 13.8%
CETP Lipid Metabolism 5.14
bar=donor   line=cohort median 		5.05 64.7%
SIRT6 Sirtuin Family 8.14
bar=donor   line=cohort median 		8.34 8.8%
SIRT1 Sirtuin Family 8.84
bar=donor   line=cohort median 		8.72 75.1%
SIRT3 Sirtuin Family 7.37
bar=donor   line=cohort median 		7.49 30.3%
IGF1R Insulin/IGF-1 Signaling 9.53
bar=donor   line=cohort median 		10.21 5.6%
KLOTHO Anti-aging 2.32
bar=donor   line=cohort median 		2.51 21.0%
APOC3 Lipid Metabolism -2.10
bar=donor   line=cohort median 		-2.11 79.8%
IL6 Inflammation 1.13
bar=donor   line=cohort median 		1.16 40.3%
TERT Telomere Maintenance 1.51
bar=donor   line=cohort median 		1.51 49.3%
IRS2 Insulin/IGF-1 Signaling 9.51
bar=donor   line=cohort median 		9.81 22.8%
TP53 Tumor Suppression 9.18
bar=donor   line=cohort median 		8.92 90.5%
SHC1 Signal Transduction 9.34
bar=donor   line=cohort median 		9.35 46.4%
ACE Signal Transduction 4.94
bar=donor   line=cohort median 		4.64 79.4%

Single Gene Lookup

- Expression: - Cohort median: - Cohort %ile: - -

Top 20 Expressed Genes

#GeneIDTypeExpression (Expression score)Count
1 MT-RNR2 17.6 0
2 EEF1A1 16.9 0
3 B2M 16.8 0
4 MT-CO1 16.6 0
5 ACTB 16.5 0
6 MT-RNR1 16.1 0
7 MT-ND4 15.8 0
8 FTL 15.7 0
9 HLA-B 15.7 0
10 FKBP8 15.6 0

Immune Marker Gene Expression (15 markers)

Inflammation / myeloid (4)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
1 S100A8 13.5
bar=donor   line=cohort median 		13.8 14.2 15.9%
2 S100A9 15.0
bar=donor   line=cohort median 		15.3 15.5 14.9%
3 IL1B 9.5
bar=donor   line=cohort median 		9.5 9.3 57.5%
4 CXCL8 10.9
bar=donor   line=cohort median 		10.6 11.4 40.3%

Neutrophil (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
5 MPO 5.6
bar=donor   line=cohort median 		6.0 6.1 11.6%
6 FCGR3B 14.6
bar=donor   line=cohort median 		14.6 14.7 48.9%

Myeloid (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
7 LYZ 13.7
bar=donor   line=cohort median 		14.3 14.3 7.0%

T cells (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
8 CD3D 10.5
bar=donor   line=cohort median 		10.2 10.4 65.4%
9 CD3E 12.1
bar=donor   line=cohort median 		11.9 12.0 66.1%

B cells (1)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
10 MS4A1 11.1
bar=donor   line=cohort median 		11.0 10.9 73.7%

NK / cytotoxic (2)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
11 NKG7 12.0
bar=donor   line=cohort median 		11.7 11.7 70.4%
12 GNLY 12.4
bar=donor   line=cohort median 		12.0 12.1 73.7%

Mitochondrial (3)

#GeneTypeExpressionvs CohortGroup MedianCohort Median%ile
16 MT-CO1 16.6
bar=donor   line=cohort median 		16.4 16.4 87.6%
17 MT-CO2 15.5
bar=donor   line=cohort median 		15.2 15.3 73.3%
18 MT-ND1 15.3
bar=donor   line=cohort median 		15.0 15.2 59.3%
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